Remediation of Working Memory in Schizophrenia
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|ClinicalTrials.gov Identifier: NCT00995553|
Recruitment Status : Completed
First Posted : October 15, 2009
Results First Posted : April 25, 2016
Last Update Posted : April 25, 2016
|Condition or disease||Intervention/treatment||Phase|
|Schizophrenia Schizoaffective Disorder||Behavioral: Cognitive Remediation Behavioral: Computer Skills||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||86 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||Remediation of Working Memory in Schizophrenia|
|Study Start Date :||January 2010|
|Actual Primary Completion Date :||April 2015|
|Actual Study Completion Date :||December 2015|
Experimental: Cognitive Remediation
A 48-session working memory focused cognitive remediation program is conducted. Training tasks have been selected from 3 software programs, PSS CogRehab, BrainTrain, and custom made N-back tasks.
Behavioral: Cognitive Remediation
This is an adaptive, computer-based cognitive training intervention. Participants will complete 3 1-hour cognitive training sessions focused on attention and working memory processes weekly for 4 months.
Placebo Comparator: Computer Skills
This is a 48-session, time matched comparison group in which participants practice keyboarding skills and the fundamentals of Microsoft Office Word, Powerpoint, and Excel programs.
Behavioral: Computer Skills
This is a computer-based course in which participants will be taught how to use Microsoft Office applications and typing skills. Participants will attend a 1-hour course three times a week four 4-months.
- Cognitive Assessment - MATRICS Consensus Cognitive Battery [ Time Frame: Post-intervention, within 2 weeks of completion of the 4 month intervention ]The Working Memory and Attention indexes of the MATRICS Consensus Cognitive Battery was used to assess near generalization of training with untrained tasks that were conceptually similar to training tasks. Each scale provide an age and gender corrected T-score. Thus, scores can range from 0-100, with a higher score indicating better performance.
- Functional Capacity - University of California, San Diego Performance-Based Skills Assessment [ Time Frame: Post-intervention, within 2 weeks of completion of the 4 month intervention ]The UPSA is a measure of the ability to apply cognitive skills to functional tasks. The total score from this scale was used. Scores may range from 0 - 100, with higher scores being better.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00995553
|United States, Minnesota|
|Minneapolis VA Health Care System, Minneapolis, MN|
|Minneapolis, Minnesota, United States, 55417|
|Principal Investigator:||Tasha Marie Nienow, PhD||Minneapolis VA Health Care System, Minneapolis, MN|