Preoperative Chemosensitivity Testing to Predict Treatment Benefit in Adjuvant Stage III Colon Cancer (PePiTA)
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| ClinicalTrials.gov Identifier: NCT00994864 |
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Recruitment Status : Unknown
Verified November 2018 by Jules Bordet Institute.
Recruitment status was: Active, not recruiting
First Posted : October 14, 2009
Last Update Posted : November 29, 2018
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| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Colon Cancer | Drug: FOLFOX | Not Applicable |
Patients with histological confirmed colon adenocarcinoma compatible with clinical stage II or III are eligible for study screening. Receipt of a signed informed consent and study inclusion should be done within 15 days after histological diagnosis. A usual workup for preoperative staging of colon cancer must be done not more than 1 month before study inclusion and include CEA assessment, positive histological sample for colon adenocarcinoma and chest and abdominal CT scan. After receipt of the written consent, the patient undergoes baseline PET/CT scan and donates blood samples for CTC and SNP analyses. Delay between baseline examinations and histological diagnosis must not exceed 21 days. The baseline examinations should be done within 1 week before beginning of the first course of FOLFOX chemotherapy. Thirteen to 15 days after chemotherapy, the PET/CT and blood sampling for CTC analysis are repeated. Standard surgery follows after 15 days but no more than 30 days from Day 1 of preoperative chemotherapy. Two frozen tissue cores are obtained during surgery and sent immediately in dry ice shipping to the central Tumour Bank (Jules Bordet Institute) or stored locally at -80°C to be sent in batches to the central tumour bank. Thereafter, the patient receives standard care, according to tumour pathological stage. In fully eligible patients, FOLFOX chemotherapy should be started not more than 45 days after surgery. In stage III patients otherwise ineligible, recommendation is to start FOLFOX chemotherapy within 45 days after surgery although such patients will not be included in the primary analysis. Treatment in case of stage II or stage IV colon cancer is left at investigator's discretion. Eleven courses of adjuvant FOLFOX are foreseen, in order to match the usual recommendation coming from the Mosaic Trial.
Follow-up procedures after completion of adjuvant treatment will follow standard European clinical recommendations for stage II and III patients. Clinical follow-up data will be obtained for all patients, including those with stage II disease, with a minimum follow-up time of three years.
| Study Type : | Interventional (Clinical Trial) |
| Estimated Enrollment : | 235 participants |
| Allocation: | N/A |
| Intervention Model: | Single Group Assignment |
| Masking: | None (Open Label) |
| Primary Purpose: | Treatment |
| Official Title: | Preoperative Chemosensitivity Testing as Predictor of Treatment Benefit in Adjuvant Stage III Colon Cancer: PePiTA Trial |
| Study Start Date : | November 2009 |
| Estimated Primary Completion Date : | December 2022 |
| Estimated Study Completion Date : | December 2022 |
| Arm | Intervention/treatment |
|---|---|
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adjuvant FOLFOX (1 pre-operative cycle)
One cycle of preoperative standard FOLFOX chemotherapy followed by eleven cycles post-operatively. PET/CT before and after the pre-operative chemotherapy cycle.
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Drug: FOLFOX
One cycle of standard FOLFOX pre-operatively followed by 11 cycles of standard adjuvant FOLFOX chemotherapy.
Other Name: FOLFOX-4 or equivalent |
- Examine the predictive value of PET-assessed tumour FDG uptake response after one course of preoperative chemotherapy on the outcome of adjuvant therapy, measured by 3-year DFS. [ Time Frame: Within 3 years after completion of adjuvant chemotherapy ]
- Examine the predictive value of PET-assessed tumour FDG uptake changes after one course of preoperative chemotherapy on OS [ Time Frame: Within 3 years after completion of adjuvant chemotherapy ]
- Evaluate the best cut-off value for relative delta SUV in assessment of preoperative chemotherapy response by FDG-PET/CT imaging. [ Time Frame: Within 3 years after completion of adjuvant chemotherapy ]
- Analyze the cost-effectiveness of preoperative chemo-sensitivity testing [ Time Frame: Within 3 years after completion of adjuvant chemotherapy ]
- Assess the predictive value of circulating tumour cells on disease-free survival [ Time Frame: Within 3 years after completion of adjuvant chemotherapy ]
- Assess the predictive value of SNPs on toxicity- and drug target-related genes on DFS [ Time Frame: Within 3 years after completion of adjuvant chemotherapy ]
- Create a frozen tumour bank for future studies [ Time Frame: Within 2 years from the beginning of study ]
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| Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Age 18 years or older
- Clinical/radiological evaluation compatible with stage III colon adenocarcinoma
- No prior chemotherapy
- No prior abdominal or pelvic irradiation
- WHO performance status 0 or 1
- Effective contraception during the study and the following six months
- Signed informed consent obtained prior to any study-specific screening procedures
- Tumour considered as curatively resectable (R0) based on standard preoperative evaluations
- White blood cell count ≥ 3×109/L with neutrophils ≥ 1.5×109/L, platelet count ≥ 100×109/L, haemoglobin ≥ 9 g/dL (5.6 mmol/L)
- Direct bilirubin ≤ 1.5×ULN; ASAT and ALAT ≤ 2.5×ULN; Alkaline phosphatase ≤ 2.5×ULN; Serum creatinine ≤ 1.5×ULN
- Delay between assessment of screening criteria and first PET/CT < 21 days
- Blood glucose < 150 mg/dl at the time of FDG administration. Insulin or oral anti-diabetic medication is not allowed on the days of PET/CT imaging.
- Compliance to the first chemotherapy course to be administered before surgery
- Delay between the first PET/CT imaging and the start of neoadjuvant FOLOFX < 7 days
- Second PET/CT imaging performed on D14 (range: D13-D15, with D1 as the first day of chemo administration)
- Delay between the second PET/CT and surgery < 7 days
- Stage III (ypTNM) as assessed after surgery
- CEA < 1.5 x ULN 1 month after surgery -
Exclusion Criteria:
- Major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to screening. Incompletely healed wounds or anticipation of the need for major surgical procedure during the course of the study
- Any suspicion of metastatic disease
- Rectal cancer located within 15 cm from the anal verge by endoscopy or under the peritoneal reflection at surgery
- Inflammatory bowel disease
- Pregnancy (absence to be confirmed by ß-hCG blood test) or breast-feeding
- History or current central nervous system disease or peripheral neuropathy
- Hypersensitivity to any of the components of study treatments
- Previous malignancy in the last five years except basal-cell carcinoma of the skin or in situ cervical carcinoma
- Clinically relevant coronary artery disease or history of myocardial infarction in the last 6 weeks or high risk of uncontrolled arrhythmia
- Medical, geographical, sociological, psychological or legal conditions that would not permit the patient to complete the study or sign informed consent
- Any significant disease which, in the investigator's opinion, would exclude the patient from the study
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00994864
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| Principal Investigator: | Alain Hendlisz, MD | Jules Bordet Institute, Brussels, Belgium |
| Responsible Party: | Jules Bordet Institute |
| ClinicalTrials.gov Identifier: | NCT00994864 |
| Other Study ID Numbers: |
PEPITA 001 EudraCT number: 2009-011445-13 |
| First Posted: | October 14, 2009 Key Record Dates |
| Last Update Posted: | November 29, 2018 |
| Last Verified: | November 2018 |
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Colonic Neoplasms Colorectal Neoplasms Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms Neoplasms by Site |
Neoplasms Digestive System Diseases Gastrointestinal Diseases Colonic Diseases Intestinal Diseases |