The Effects of Broccoli Sprout Extract on Obstructive Lung Disease

This study has been completed.
Information provided by (Responsible Party):
Robert Brown, Johns Hopkins University Identifier:
First received: October 13, 2009
Last updated: August 31, 2015
Last verified: August 2015
The purpose of this study is to examine whether broccoli sprout extract can effect lung function measurements in individuals with asthma and COPD.

Condition Intervention
Drug: broccoli sprout extract

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science

Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • The primary outcome is the change in bronchodilation and bronchoprotection after broccoli sprout extract [ Time Frame: end of study ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Change in biomarkers, Change in inflammatory mediators, Change in airway distensibility, Change in parenchyma [ Time Frame: end of study ] [ Designated as safety issue: No ]

Estimated Enrollment: 150
Study Start Date: October 2009
Study Completion Date: August 2015
Primary Completion Date: August 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: broccoli sprout extract Drug: broccoli sprout extract
consumption of broccoli sprout extract for 2 weeks


Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • asthma
  • COPD

Exclusion Criteria:

  • currently on chronic oral steroid medications
  • current respiratory symptoms
  • pregnant
  • FEV1 less than 40% predicted at baseline
  • extreme degrees of bronchial hyperreactivity
  • recent respiratory infection (<3 weeks)
  • unstable symptoms in the prior month
  • a history of intubation for respiratory symptoms within the past year
  • any history of cardiac disease.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00994604

United States, Maryland
Johns Hopkins Medical Institutions
Baltimore, Maryland, United States, 21205
Sponsors and Collaborators
Johns Hopkins University
  More Information

No publications provided

Responsible Party: Robert Brown, Professor, Johns Hopkins University Identifier: NCT00994604     History of Changes
Other Study ID Numbers: RB-001
Study First Received: October 13, 2009
Last Updated: August 31, 2015
Health Authority: United States: Food and Drug Administration processed this record on November 27, 2015