The Effects of Broccoli Sprout Extract on Obstructive Lung Disease

This study has been completed.
Information provided by (Responsible Party):
Robert Brown, Johns Hopkins University Identifier:
First received: October 13, 2009
Last updated: August 31, 2015
Last verified: August 2015
The purpose of this study is to examine whether broccoli sprout extract can effect lung function measurements in individuals with asthma and COPD.

Condition Intervention
Drug: broccoli sprout extract

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science

Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • The primary outcome is the change in bronchodilation and bronchoprotection after broccoli sprout extract [ Time Frame: end of study ]

Secondary Outcome Measures:
  • Change in biomarkers, Change in inflammatory mediators, Change in airway distensibility, Change in parenchyma [ Time Frame: end of study ]

Estimated Enrollment: 150
Study Start Date: October 2009
Study Completion Date: August 2015
Primary Completion Date: August 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: broccoli sprout extract Drug: broccoli sprout extract
consumption of broccoli sprout extract for 2 weeks


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • asthma
  • COPD

Exclusion Criteria:

  • currently on chronic oral steroid medications
  • current respiratory symptoms
  • pregnant
  • FEV1 less than 40% predicted at baseline
  • extreme degrees of bronchial hyperreactivity
  • recent respiratory infection (<3 weeks)
  • unstable symptoms in the prior month
  • a history of intubation for respiratory symptoms within the past year
  • any history of cardiac disease.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00994604

United States, Maryland
Johns Hopkins Medical Institutions
Baltimore, Maryland, United States, 21205
Sponsors and Collaborators
Johns Hopkins University
  More Information

Responsible Party: Robert Brown, Professor, Johns Hopkins University Identifier: NCT00994604     History of Changes
Other Study ID Numbers: RB-001 
Study First Received: October 13, 2009
Last Updated: August 31, 2015 processed this record on January 19, 2017