Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development
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|ClinicalTrials.gov Identifier: NCT00993902|
Recruitment Status : Completed
First Posted : October 14, 2009
Last Update Posted : October 14, 2009
|Condition or disease||Intervention/treatment||Phase|
|Infertility||Procedure: Intrauterine insemination (single) Procedure: Double intrauterine insemination||Phase 4|
Metaanalysis for the effects of double IUI demonstrates that effects of this procedure is not different from single IUI. It is known that nearly 25% of coh cycles is evident by monofollicular development.For this reason it is possible that this monofollicular cycles in the studies could decrease the effects of double IUI.
- Patients with unexplained infertility or mild male factor infertility whom admitted to the COH+IUI programme in our infertility unit.
- Female age <37 years old.
- Baseline FSH <12 mIU/L
- Total antral follicle count>6
- During the first three cycles of COH+IUI
- Minimum 2 follicles >16 mm at the day of HCG.
Ongoing pregnancy rates
The effects of different coh regimens (CC,FSH,CC+FSH)on the outcomes.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||228 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||May 2008|
|Actual Primary Completion Date :||May 2009|
|Actual Study Completion Date :||July 2009|
Sham Comparator: Single IUI
Single IUI will be carried on after 36-38 hours of HCG administration
Procedure: Intrauterine insemination (single)
Single IUI after 36-38 hours of HCG
Other Name: Group I
|Active Comparator: Double IUI||
Procedure: Double intrauterine insemination
Double insemination after 18 and 40 hours of HCG administration.
Other Name: Grup II
- ongoing pregnancy rates [ Time Frame: pregnancy >12 weeks of gestation ]
- The effects of different coh regimens on outcomes [ Time Frame: 14 days after IUI procedure ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00993902
|Baskent University Medical Faculty Obstetric and Gynecelogy Department, Infertility and IVF unit|
|Adana, Turkey, 01120|