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CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome

This study has been completed.
Information provided by:
Chonnam National University Hospital Identifier:
First received: October 7, 2009
Last updated: NA
Last verified: October 2009
History: No changes posted

The aim of this study is to investigate the expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome.

Thirty-three patients with dry eye (16 Sjögren's syndrome and 17 non-Sjögren's syndrome patients) and 15 control subjects were recruited. The concentrations of CXCL9, CXCL10, and CXCL11 in tears were measured using enzyme-linked immunosorbent assay. The correlation between chemokine levels and tear film and ocular surface parameters was analyzed. Expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the conjunctiva was evaluated using immunohistochemistry. Flow cytometry was performed to count CXCR3+ cells and CXCR3+CD4+ cells in the conjunctiva.

Dry Eye Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the Tear Film and Ocular Surface of Patients With Dry Eye Syndrome

Resource links provided by NLM:

Further study details as provided by Chonnam National University Hospital:

Biospecimen Retention:   Samples Without DNA
tears, conjunctiva

Enrollment: 48
Study Start Date: February 2008
Study Completion Date: December 2008
Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Normal control subjects
Normal control subjects who did not show the clinical symptom and findings of dry eye syndrome.
dry eye patients
Patients with dry eye syndrome who had symptoms of dry eye for more than 3 months, low tear film break up time (BUT, ≤7 sec), low Schirmer test (<10 mm), low tear clearance rate (<8X), and positive fluorescein or rose bengal vital staining (≥3) and were not treated with anti-inflammatory agents such as topical cyclosporine or steroids were included in the study.


Ages Eligible for Study:   24 Years to 77 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Primary care clinic

Inclusion Criteria:

  • clinical diagnosis of dry eye syndrome

Exclusion Criteria:

  • active ocular infection or inflammation not associated with dry eye
  • drug toxicity
  • contact lens wear
  • ocular allergy
  • ocular surgery within the last 3 months
  • lid or lash abnormalities
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Please refer to this study by its identifier: NCT00991679

Korea, Republic of
Chonnam National University Hospital
Gwangju, Chonnam, Korea, Republic of, 501-757
Sponsors and Collaborators
Chonnam National University Hospital
Study Director: Kyung-Chul Yoon, MD, PhD Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Kyung-Chul Yoon, MD/ Assisted professor, Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea Identifier: NCT00991679     History of Changes
Other Study ID Numbers: I-2007-12-111
Study First Received: October 7, 2009
Last Updated: October 7, 2009

Keywords provided by Chonnam National University Hospital:
Dry eye syndrome
CXCL9 chemokine
CXCL10 chemokine
CXCL11 chemokine
CXCR3 receptor

Additional relevant MeSH terms:
Keratoconjunctivitis Sicca
Dry Eye Syndromes
Pathologic Processes
Conjunctival Diseases
Eye Diseases
Corneal Diseases
Lacrimal Apparatus Diseases processed this record on April 26, 2017