Long Term Vascular Changes in Type 1 Diabetes (DM09)
The main purpose of this study is to investigate progression of late complications of diabetes during the last ten years in a well characterized cohort of type 1 diabetes with a long duration of the disease, and to define factors responsible for the progression of late complications.
Diabetes Mellitus, Type 1
Coronary Heart Disease
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Long Term Vascular Changes in Type 1 Diabetes, Clinical Aspects and Biological Markers|
- Fatal and non fatal cardiovascular disease (CVD) and stroke [ Time Frame: One year ] [ Designated as safety issue: No ]
- Vessel area stenosis [ Time Frame: One year ] [ Designated as safety issue: Yes ]
Biospecimen Retention: Samples With DNA
whole blood, serum, white cells, urine, tissue
|Study Start Date:||April 2009|
|Estimated Study Completion Date:||May 2010|
|Estimated Primary Completion Date:||April 2010 (Final data collection date for primary outcome measure)|
|Diabetes, type 1|
Despite intensively research in the field of hyperglycaemia and coronary heart disease in type 1 diabetes it is still not known in detail how hyperglycaemia leads to damage of the vessels.
The aims of the present proposal are therefore two-fold:
- To study in detail the progression of atherosclerosis (and micro vascular complications) in a well characterized cohort of type 1 diabetes with a long duration of the disease. This project will be a continuation of the Oslo study, a cohort started in 1982, with the last follow-up study in 1999/2000.
- To define factors responsible for the progression of coronary heart disease (and micro vascular complications) in this cohort.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00991575
|Oslo University hospital, Aker|
|Oslo, Norway, 0514|
|Principal Investigator:||Kristian F Hanssen, Professor MD||Oslo university hospital, Aker, Norway|