Collagen Analysis and Genetic Analysis of Families With Tendency to Hernias
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|ClinicalTrials.gov Identifier: NCT00991484|
Recruitment Status : Unknown
Verified October 2010 by Herlev Hospital.
Recruitment status was: Recruiting
First Posted : October 8, 2009
Last Update Posted : October 13, 2010
|Condition or disease|
Research has shown relationship between hernias and collagen subtype I/III ratio, biomarkers such as MMP's TIMP's and other diseases such as Ehlers-Danlos, Marfans syndrome, AAA (abdominal aortic aneurysms), diverticulosis and rectal prolapse. Furthermore has research raised hypothesis about inheritance of hernias. The investigators are performing genetic examination combined with analysis of collagen and biomarkers on patients belonging to families with tendency to hernias.
Other examinations performed on the patients enrolled in this study:
- Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms.
- Beightons score to evaluate the degree of joint hypermobility.
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Official Title:||Collagen-subtype Analysis in Subcutaneous Tissue and Genetic Analysis on Patients From Families With a Tendency to Hernias|
|Study Start Date :||December 2009|
|Estimated Primary Completion Date :||December 2010|
|Estimated Study Completion Date :||June 2011|
|individuals from hernia-family|
- Expression of collagen-genes or other relevant genes by microarray analysis compared with presence of hernia [ Time Frame: 1 year ]
- Amount of collagen subtypes measured subcutaneously. [ Time Frame: 1 year ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00991484
|Contact: Jakob Burcharth, MD||0045 44884488 ext firstname.lastname@example.org|
|DK-2730, Herlev, Herlev, Denmark, 2730|
|Contact: jakob Burcharth, MS 004544884488 email@example.com|
|Principal Investigator: Jakob Burcharth, MD|
|Study Director:||Jacob Rosenberg, Prof. MD||Herlev Hospital|
|Principal Investigator:||Jakob Burcharth, MD||Herlev Hospital|