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Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase

This study has been completed.
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals ) Identifier:
First received: October 6, 2009
Last updated: February 21, 2017
Last verified: February 2017

To date there are no approved effective therapies for the treatment of cryopyrin-associated periodic syndromes (CAPS) including Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), or Neonatal Onset Multisystem Inflammatory Disease (NOMID) in Japan.

The study will assess the efficacy and safety of canakinumab in Japanese patients with cryopyrin-associated periodic syndromes (CAPS). In previous and currently ongoing CAPS studies (CACZ885A2102, CACZ885D2201, CACZ885D2304, CACZ885D2306), it has been observed that treatment with canakinumab in patients with CAPS contributed to ensure absence of relapse, to improve signs and symptoms and to prevent secondary disease complications. However, no Japanese patients have been included in those studies. This study will allow access for Japanese patients to a new potentially efficacious treatment for CAPS patients with a convenient dosing regimen.

Condition Intervention Phase
Cryopyrin-associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome
Muckle-Wells Syndrome
Neonatal Onset Multisystem Inflammatory Disease
Drug: canakinumab
Phase 3

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: No masking
Primary Purpose: Treatment
Official Title: An Open-label, Efficacy and Safety Study of Canakinumab (Anti-interleukin-1β Monoclonal Antibody) Administered for 6 Months (24 Weeks) in Japanese Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease, Followed by an Extension Phase to Provide Canakinumab to Study Patients Until it is Approved and Marketed in Japan

Resource links provided by NLM:

Further study details as provided by Novartis:

Primary Outcome Measures:
  • Number of participants without a relapse [ Time Frame: 24 weeks ]

Secondary Outcome Measures:
  • Number of complete responder patients [ Time Frame: 29 days ]
  • Clinical improvement (or resolution) with regards to: central nervous system (CNS) involvement, eye disease, hearing impairment, skin disease, joint disease, fever, and kidney function [ Time Frame: 24 months ]
  • Number of patients experiencing a relapse during the entire study [ Time Frame: 24 months ]
  • How much canakinumab is contained in the patients' blood (pharmacokinetics) and what are the effect of canakinumab on the patients' body (pharmacodynamic) [ Time Frame: 24 months ]
  • Presence of antibody against canakinumab [ Time Frame: 24 months ]

Enrollment: 19
Study Start Date: October 2009
Study Completion Date: February 2012
Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: canakinumab Drug: canakinumab


Ages Eligible for Study:   2 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. At study entry, patients should have a clinical diagnosis of FCAS, MWS or NOMID and require medication. At the time of screening, patients can be either untreated or treated with other medication.
  2. Presence, or history of at least 2 of the following symptoms:

    • For NOMID patients:

      • Typical NOMID urticarial rash
      • Signs of central nervous system (CNS) involvement such as increased intracranial pressure and/or papilledema and/or cerebral spinal fluid pleiocytosis and/or stroke and/or seizures, and/or sensorineural hearing loss
      • Typical arthropatic changes on X-rays: epiphysal and/or patellar overgrowth With start of NOMID symptoms before or at 6 months of age
    • For MWS patients:

      • periodic fever
      • headache/migraine
      • arthralgia
      • urticarial skin rash
      • conjunctivitis
      • myalgia
      • sensorineural hearing impairment
    • For FCAS patients:

      • urticarial skin rash
      • fever/chills
      • conjunctivitis
      • joint pain
  3. Patients requiring oral steroids, NSAIDs and/or disease-modifying antirheumatic drugs (DMARDs) can be enrolled if they are on a stable dose (oral steroids: < 20 mg/day or < or = 0.4 mg/kg prednisone or prednisone equivalent, whichever applies) for at least 4 weeks prior to the screening visit.
  4. Able to communicate with the investigator and comply with the requirements of the study (for children the parent can assist when necessary).

Exclusion Criteria:

  1. Pregnant or nursing (lactating) women.
  2. All women capable of becoming pregnant unless they are postmenopausal or are using one or more methods of contraception.
  3. Participation in any other study within 30 days
  4. Infection with HIV, Hepatitis B or C.
  5. Live vaccinations within 3 months prior to the start of the trial, during the trial, and up to 3 months following the last dose.
  6. History of drug or alcohol abuse within the 12 months prior to dosing.
  7. Donation or loss of 400 mL or more of blood within 8 weeks prior to dosing for adults.
  8. History of significant medical conditions, which in the doctor's opinion would exclude the patient from participating in this trial.
  9. History of renal transplantation.
  10. Presence of any additional rheumatic diseases or significant systemic diseases. For example, major chronic infectious/ inflammatory/ immunologic disease (such as inflammatory bowel disease, psoriatic arthritis, spondyloarthropathy, systemic lupus erythematosus in addition to the autoinflammatory disease).
  11. Presence of any of the following laboratory abnormalities: ALT or AST greater than 2 times the upper limit of normal (ULN), platelet count less than 100x109/L.
  12. History of recurrent and/or evidence of clinically significant active bacterial, fungal, or viral infections.
  13. History of contact with patients with suspected tuberculosis symptoms; or history or complication of tuberculosis infection.
  14. Use of the following therapies:

    • Etanercept in the 4 weeks prior to the baseline visit (Day 1) and thereafter
    • Adalimumab in the 8 weeks prior to the baseline visit (Day 1) and thereafter
    • Infliximab in the 12 weeks prior to the baseline visit (Day 1) and thereafter
    • Rituximab in the 26 weeks prior to the baseline visit (Day 1) and thereafter
    • Tocilizumab in the 3 weeks prior to the baseline visit (Day 1) and thereafter
    • Any other investigational biologics in the 8 weeks prior to the baseline visit (Day 1) and thereafter (with the exception of anakinra therapy-see below)
    • Anakinra therapy after the baseline visit (Day 1). Last anakinra injection should occur not less than 6 hours prior to the canakinumab injection at Day 1
    • Leflunomide in the 4 weeks prior to the baseline visit (Day 1) and thereafter. After the completion of leflunomide treatment a cholestiramine in dose 8 g 3 times per day for 14 days is recommended.
    • Thalidomide in the 4 weeks prior to the baseline visit (Day 1) and thereafter
    • Cyclosporine in the 4 weeks prior to the baseline visit (Day 1) and thereafter
    • i.v. immunoglobulin (i.v. Ig) in the 8 weeks prior to the baseline visit (Day 1) and thereafter
    • 6-Mercaptopurine, azathioprine, cyclophosphamide, or chlorambucil in the 12 weeks prior to the baseline visit (Day 1) and thereafter
    • Dapsone, mycophenolate mofetil in the 3 weeks prior to the baseline visit (Day 1) and thereafter
    • > or = 20 mg/day or >0.4 mg/kg, whichever applies, of prednisone or prednisone equivalent in the 4 week prior to the baseline visit (Day 1) and thereafter
    • Methyl prednisone pulse therapy in the 4 weeks prior to baseline visit and thereafter
  15. History of allergic reaction to similar drugs. No additional exclusions may be applied by the doctor, in order to ensure that the study population will be representative of all eligible patients.

Other protocol-defined inclusion/exclusion criteria may apply

  Contacts and Locations
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Please refer to this study by its identifier: NCT00991146

Novartis Investigative Site
Fukuoka-city, Fukuoka, Japan, 812-8582
Novartis Investigative Site
Yokohama-city, Kanagawa, Japan, 236-0004
Novartis Investigative Site
Kyoto-city, Kyoto, Japan, 606-8507
Sponsors and Collaborators
Novartis Pharmaceuticals
Study Director: Novartis Pharmaceuticals Novartis Pharmaceuticals
  More Information

Additional Information:
Responsible Party: Novartis Pharmaceuticals Identifier: NCT00991146     History of Changes
Other Study ID Numbers: CACZ885D2308
Study First Received: October 6, 2009
Last Updated: February 21, 2017

Keywords provided by Novartis:
cryopyrin-associated periodic syndromes
Familial Cold Autoinflammatory Syndrome
Muckle-Wells Syndrome
Neonatal Onset Multisystem Inflammatory Disease
systemic autoinflammatory disease
human monoclonal anti-human interleukin-1beta (IL-1beta)antibody
autosomal dominant
familial autoinflammatory syndrome

Additional relevant MeSH terms:
Hereditary Autoinflammatory Diseases
Cryopyrin-Associated Periodic Syndromes
Pathologic Processes
Genetic Diseases, Inborn
Skin Diseases, Genetic
Skin Diseases
Skin Diseases, Infectious
Connective Tissue Diseases
Leukocyte Disorders
Hematologic Diseases
Antibodies, Monoclonal
Immunologic Factors
Physiological Effects of Drugs processed this record on May 23, 2017