Effect of Aerobic Training on Asthmatic Patients
The investigators hypothesize that aerobic training can reduce anxiety, depression and airway inflammation and those benefits may be related to changes in autonomic system.
|Study Design:||Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Effect of Aerobic Training on Psychosocial Morbidity, Symptoms, Airway Inflammation and Autonomic Modulation in Asthmatic Patients|
- psychosocial morbidity and airway inflammation [ Time Frame: 3 months ] [ Designated as safety issue: Yes ]
- autonomic modulation, aerobic capacity, pulmonary function [ Time Frame: 3 months ] [ Designated as safety issue: Yes ]
|Study Start Date:||January 2007|
|Study Completion Date:||September 2009|
|Primary Completion Date:||September 2009 (Final data collection date for primary outcome measure)|
Improve medicine use Self control asthma crisis Ambient hygiene
Other: Aerobic training
Other Name: Exercise conditioning
One-hundred patients with moderate or severe persistent asthma, age ranging from 20 to 50 years-old recruited after a medical consultation. Asthma diagnosis based on GINA1 and patients were under medical treatment for at least 6-months and considered clinically stable (no crises and changes in medication for at least 30 days). Patients diagnosed with cardiovascular, pulmonary or musculoskeletal diseases impairing exercise training were excluded.
Experimental Design: Patients were studied between 2 medical consultation to avoid changes in medication during the study and patients were randomized (by drawing lots) into either Control or Training groups. CG was submitted to a 4-hour educational program and a breathing exercise program and TG was submitted to the same CG procedures plus an aerobic training program individually based on VO2max. Before and after the intervention, patients performed pulmonary function test and cardiopulmonary exercise testing and as well as fulfilled questionnaires to quantify asthma specific HRQL and anxiety and depression levels. Asthma daily symptoms were evaluated monthly.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00989365
|Clinical Hospital, School of Medicine, University of São Paulo|
|São Paulo, Brazil, 05403-000|
|Study Chair:||Celso RF Carvalho, PhD||School of Medicine, University of São Paulo|