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The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems? (ECTAug)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2009 by University of Iowa.
Recruitment status was:  Not yet recruiting
Information provided by:
University of Iowa Identifier:
First received: October 1, 2009
Last updated: NA
Last verified: October 2009
History: No changes posted
The purpose of this study is to determine whether memantine will enhance the therapeutic of effect on depression and prevent memory and other cognitive problems caused by ECT.

Condition Intervention
Major Depressive Disorder
Drug: memantine
Drug: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Memantine Augmentation of Electroconvulsive Therapy in Patients With Major Depression

Resource links provided by NLM:

Further study details as provided by University of Iowa:

Primary Outcome Measures:
  • Assessment of whether Memantine protects memory and cognitive impairment caused by ECT. [ Time Frame: 6 to 8 weeks ]

Secondary Outcome Measures:
  • Whether memantine will improve response of Depression to Electroconvulsive therapy. [ Time Frame: 6-8 weeks ]

Estimated Enrollment: 50
Study Start Date: November 2009
Estimated Study Completion Date: May 2012
Estimated Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Memantine arm
Patient receiving ECT and Memantine
Drug: memantine
patient will receive 5mg daily for 7day then 10 mgm daily
Other Name: Namenda
Placebo Comparator: placebo
25 patients receiving ECT will will receive placebo
Drug: memantine
patient will receive 5mg daily for 7day then 10 mgm daily
Other Name: Namenda
Drug: Placebo
will give placebo that looks like memantine

Detailed Description:
Patients will be assigned randomly either to a treatment group or a placebo groups. All patients in both groups will be receiving standard ECT. The treatment group will receive memantine. All patients will be given a battery of cognitive tests and test of depression before ECT treatments start, after the 6th ECT treatment and after the completions of ECT. An analysis will be performed to see if memantine causes any impact on the response to ECT and prevents memory and cognitive impairment.

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Meets criteria for Major Depressive disorder

Exclusion Criteria:

  • Neurological disease
  • Mental retardation
  • Seizure disorder
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00988663

Contact: Jerry L. Lewis, MD 319-384 5630
Contact: Laurie M McCormick, MD 319-384-7136

United States, Iowa
University of Iowa hosptitals and clinic Not yet recruiting
Iowa City, Iowa, United States, 50208
Contact: Jerry L Lewis, MD    319-384-5630   
Contact: Laurie M McCormick, MD    319-384-7136   
Principal Investigator: Jerry L Lewus, MD         
Sponsors and Collaborators
University of Iowa
Principal Investigator: Jerry L Lewis, MD University of Iowa Hospitals and Clinic
  More Information

Responsible Party: Jerry Lewis MD, professor of psychiatry, Univery of Iowa Hospitals and Clinics Identifier: NCT00988663     History of Changes
Other Study ID Numbers: Memantine ECT trial 
Study First Received: October 1, 2009
Last Updated: October 1, 2009

Keywords provided by University of Iowa:
electroconvulsive therapy
cognitive function

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Mood Disorders
Mental Disorders
Behavioral Symptoms
Antiparkinson Agents
Anti-Dyskinesia Agents
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents processed this record on February 24, 2017