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Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise) (CEE)

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ClinicalTrials.gov Identifier: NCT00988299
Recruitment Status : Completed
First Posted : October 2, 2009
Last Update Posted : December 6, 2011
National Institute on Aging (NIA)
Information provided by (Responsible Party):
Washington University School of Medicine

Brief Summary:

In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:

  1. decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise;
  2. increase in resting metabolic rate 48 hours after exercise;
  3. increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise;
  4. decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.

Condition or disease Intervention/treatment
Aging Other: exercise

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 26 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Official Title: Energy Expenditure Responses to Acute Exercise in Older Women
Study Start Date : October 2009
Primary Completion Date : December 2011
Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Intervention Details:
    Other: exercise
    exercise sessions at 45% and 60% of maximum effort

Primary Outcome Measures :
  1. non-exercise activity calorie expenditure [ Time Frame: 2 days after exercise sessions ]

Secondary Outcome Measures :
  1. resting metabolic rate [ Time Frame: 2 days after exercise sessions ]

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. Women
  2. Age 60-75 years
  3. normal weight
  4. Weight-stable (± 5%) within the previous 3 months
  5. Non-smoking for last year
  6. Able to provide own transportation to study visits
  7. Not currently involved in any other research study
  8. Willing and able to participate in all aspects of the trial including research testing
  9. Willing to give informed consent to participate

Exclusion Criteria:

  1. Self-reported significant cardiovascular disease
  2. Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease
  3. Medications known to affect exercise performance or metabolism
  4. Excess caffeine use (> 500mg/day)
  5. Any self-reported contraindications to exercise
  6. Clinical depression
  7. Abnormal cognitive function -

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00988299

United States, Missouri
Washington University School of Medicine
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University School of Medicine
National Institute on Aging (NIA)
Principal Investigator: Xuewen Wang, PhD Washington University School of Medicine

Responsible Party: Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT00988299     History of Changes
Other Study ID Numbers: 09-0864
K99AG031297 ( U.S. NIH Grant/Contract )
First Posted: October 2, 2009    Key Record Dates
Last Update Posted: December 6, 2011
Last Verified: December 2011

Keywords provided by Washington University School of Medicine:
energy expenditure