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Resistance and/or Endurance Training, What is Most Effective in Prevention of Cardiovascular Diseases?

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ClinicalTrials.gov Identifier: NCT00986024
Recruitment Status : Completed
First Posted : September 29, 2009
Last Update Posted : December 13, 2012
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Brief Summary:
The aim of the present study was to evaluate the effects of aerobic interval training versus strength training or a combination of these regimes on factors comprising the metabolic syndrome in order to find the most effective exercise regime for patients with metabolic syndrome.

Condition or disease Intervention/treatment
Metabolic Syndrome Behavioral: aerobic exercise Behavioral: strength training

Detailed Description:

In the Western world, approximately 25% of young to middle-aged adults have metabolic syndrome. There seem to be a strong age-dependence in the prevalence of the metabolic syndrome, but the incidence rises rapidly within adolescents and middle-aged groups and follows the development of obesity in the general population. Metabolic syndrome confers an increased risk of coronary heart disease, cardiovascular disease, and premature death; therefore, effective and affordable strategies to combat the syndrome would be of great individual and social importance.

Despite the general agreement that moderate-intensity physical activity for a minimum of 30 min five days per week or vigorous-intensity aerobic physical activity for a minimum of 20 min three days a week promote and maintain health, the optimal training regime to treat metabolic syndrome and its associated cardiovascular abnormalities remains uncertain.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 31 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Strength Training Versus Aerobic Interval Training to Modify Risk Factors of the Metabolic Syndrome
Study Start Date : August 2006
Primary Completion Date : March 2007
Study Completion Date : March 2007

Arm Intervention/treatment
Experimental: aerobic exercise Behavioral: aerobic exercise
carried out 3 times per week for 12 weeks
Experimental: strength training Behavioral: strength training
carried out 3 times per week for 12 weeks
No Intervention: control group

Primary Outcome Measures :
  1. proinflammatory markers [ Time Frame: 12 weeks ]
    circulating interleukin-18 and interleukin-6

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Having metabolic syndrome according to international diabetes foundations definition (IDF).

Exclusion Criteria:

  • Unstable angina pectoris
  • Uncompensated heart failure
  • Myocardial infarction during the past 4 weeks
  • Complex ventricular arrhythmias
  • Kidney failure

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00986024

Sponsors and Collaborators
Norwegian University of Science and Technology
Study Director: Ulrik Wisløff, md prof Norwegian University of Science and Technology

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00986024     History of Changes
Other Study ID Numbers: 460150
First Posted: September 29, 2009    Key Record Dates
Last Update Posted: December 13, 2012
Last Verified: December 2012

Keywords provided by Norwegian University of Science and Technology:
Exercise therapy

Additional relevant MeSH terms:
Metabolic Syndrome X
Pathologic Processes
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases