Physical Activity in Patients With Systemic Lupus Erythematosus (LESPA)
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ClinicalTrials.gov Identifier: NCT00985803 |
Recruitment Status : Unknown
Verified October 2009 by Federal University of São Paulo.
Recruitment status was: Enrolling by invitation
First Posted : September 28, 2009
Last Update Posted : October 8, 2009
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The purpose of this study is to check the improvement in quality of life in patients with systemic lupus incorporated into a routine of physical activity.
Randomized controlled blinded trial, 63 patients aged 42.9 ± 14.4 and diagnosis of systemic lupus erythematosus (SLE) according to the criteria of the College American Rheumatology, 1997. After randomization patients were allocated into 3 groups, control group (CG) (n = 21), training cardiovascular (CT) (n = 20), resistance training (RT) (n = 22), performing 12 weeks of intervention with a frequency of three times weeks and were evaluated at two different times (T0 and T12). As primary outcome quality of life was assessed by the inventory Generic Assessment of quality of life by the Medical Outcomes Study 36 -- Healthy ItemShort Form Survey (SF36) and as secondary outcomes functional capacity evaluation of pain symptoms (visual scale analogue pain [VAS]), intensity of symptoms of depression (Beck Depression Inventory [BDI]), index of disease activity (Systemic Lupus Disease Activity Inventory Erythmatodud [SLEDAI]), capacity aerobic (walking test of 12 minutes [T12]), subjective perception effort (subjective scale of Borg [Borg]), limb muscle strength lower (analog dynamometer [strength]), electrical activity member lower (surface electromyography [EMG]), amount of products (inventory amount of Medicines).
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Systemic Lupus Erythematosus | Other: Physical Activity: Cardio training (CT) Other: Physical Activity: Endurance exercise training (ET) | Phase 1 |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 60 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Treatment |
Official Title: | Comparison of Cardiovascular Training Versus Resistance Training In Patients With Systemic Lupus Erythematosus: Controlled Randomized Clinical Trial |
Study Start Date : | November 2009 |
Primary Completion Date : | November 2009 |
Study Completion Date : | March 2010 |

Arm | Intervention/treatment |
---|---|
No Intervention: Group Control | |
Experimental: Endurance |
Other: Physical Activity: Endurance exercise training (ET)
The experimental group of resistance training will carry out the training with 8 kinds of training session with 12 reps with that load will vary according to the 1 RM test. The composition of the training session is 10 minutes of heating and stretching, 40 minutes of cardiovascular training and 10 minutes of cooling. |
Experimental: Cardiovascular |
Other: Physical Activity: Cardio training (CT)
The experimental group of resistance training will carry out the training with 8 kinds of training session with 12 reps with that load will vary according to the 1 RM test. The composition of the training session is 10 minutes of heating and stretching, 40 minutes of cardiovascular training and 10 minutes of cooling. |
- Life quality [ Time Frame: 12 weeks ]
- Pain [ Time Frame: 12 weeks ]
- Strength [ Time Frame: 12 weeks ]
- Electromyography [ Time Frame: 12 weeks ]
- Aerobic capacity [ Time Frame: 12 weeks ]

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Ages Eligible for Study: | 18 Years to 55 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
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(American College of Rheumatology). It is necessary to have the presence of room between the elevens criteria for diagnosis:
- malar erythema
- discoid lesions
- photosensitivity
- oral or nasal ulcers
- arthritis
- serositis
- renal
- neurological
- hematological
- immunological changes
- antinuclear antibodies.
Exclusion Criteria:
- Patients with hemoglobin level 10gm/dL, sequelae of cardiovascular events, - Respiratory diseases (pulmonary hypertension, pulmonary fibrosis
- Bronchitis, asthma, emphysema)
- Heart failure (NYHA> II)
- History of myocardial ischemia or heart
- Blood pressure> 100 mm Hg.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00985803
Brazil | |
AmbulatoAmbulatory Specialty Interlagos - General Hospital Grajaú - Association Congregation Santa Catarina | |
São Paulo, Brazil, 04671300 |
Principal Investigator: | Marcelo I Abrahão | University Federal of São Paulo |
Responsible Party: | Marcelo Ismael Abrahão, Federal University of São Paulo |
ClinicalTrials.gov Identifier: | NCT00985803 |
Other Study ID Numbers: |
MAbrahao |
First Posted: | September 28, 2009 Key Record Dates |
Last Update Posted: | October 8, 2009 |
Last Verified: | October 2009 |
Systemic Lupus Erythematosus Activity Physical Activity Disease,trials randomized |
Lupus Erythematosus, Systemic Connective Tissue Diseases Autoimmune Diseases Immune System Diseases |