S8516-S8736-S9125-S9240 Research Study of Genes in Tissue Samples From Patients With B-cell Non-Hodgkin Lymphoma
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at genes in tissue samples from patients with B-cell non-Hodgkin lymphoma.
Genetic: polymorphism analysis
Other: laboratory biomarker analysis
Other: pharmacogenomic studies
|Study Design:||Time Perspective: Retrospective|
|Official Title:||Pharmacogenomics of Oxidative Stress-Related Genes in Lymphoma|
- Association of polymorphisms in oxidative stress-related genes with overall survival and/or progression-free survival [ Time Frame: retrospectively ] [ Designated as safety issue: No ]
- Association of polymorphisms in these genes with rate of grade 4-5 hematologic toxicity [ Time Frame: retrospectively ] [ Designated as safety issue: No ]
|Study Start Date:||April 2009|
|Study Completion Date:||June 2014|
|Primary Completion Date:||June 2014 (Final data collection date for primary outcome measure)|
- To determine if toxicity following treatment for lymphoma varies according to genetic polymorphisms in oxidative stress-related genes (i.e., SOD2, CAT, GPX1, GSTM1, and GSTP1).
- To assess whether these genetic polymorphisms are associated with progression-free survival and/or overall survival in these patients treated for lymphoma.
OUTLINE: Previously collected samples are used for biomarker analysis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00985699
|Study Chair:||Margaret M. Briehl, PhD||University of Arizona|