S8516-S8736-S9125-S9240 Research Study of Genes in Tissue Samples From Patients With B-cell Non-Hodgkin Lymphoma
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|ClinicalTrials.gov Identifier: NCT00985699|
Recruitment Status : Completed
First Posted : September 28, 2009
Last Update Posted : July 24, 2014
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at genes in tissue samples from patients with B-cell non-Hodgkin lymphoma.
|Condition or disease||Intervention/treatment|
|Lymphoma||Genetic: polymorphism analysis Other: laboratory biomarker analysis Other: pharmacogenomic studies|
- To determine if toxicity following treatment for lymphoma varies according to genetic polymorphisms in oxidative stress-related genes (i.e., SOD2, CAT, GPX1, GSTM1, and GSTP1).
- To assess whether these genetic polymorphisms are associated with progression-free survival and/or overall survival in these patients treated for lymphoma.
OUTLINE: Previously collected samples are used for biomarker analysis.
|Study Type :||Observational|
|Actual Enrollment :||337 participants|
|Official Title:||Pharmacogenomics of Oxidative Stress-Related Genes in Lymphoma|
|Study Start Date :||April 2009|
|Actual Primary Completion Date :||June 2014|
|Actual Study Completion Date :||June 2014|
- Association of polymorphisms in oxidative stress-related genes with overall survival and/or progression-free survival [ Time Frame: retrospectively ]
- Association of polymorphisms in these genes with rate of grade 4-5 hematologic toxicity [ Time Frame: retrospectively ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00985699
|Study Chair:||Margaret M. Briehl, PhD||University of Arizona|