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S8516-S8736-S9125-S9240 Research Study of Genes in Tissue Samples From Patients With B-cell Non-Hodgkin Lymphoma

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ClinicalTrials.gov Identifier: NCT00985699
Recruitment Status : Completed
First Posted : September 28, 2009
Last Update Posted : July 24, 2014
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Southwest Oncology Group

Brief Summary:

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at genes in tissue samples from patients with B-cell non-Hodgkin lymphoma.


Condition or disease Intervention/treatment
Lymphoma Genetic: polymorphism analysis Other: laboratory biomarker analysis Other: pharmacogenomic studies

Detailed Description:

OBJECTIVES:

  • To determine if toxicity following treatment for lymphoma varies according to genetic polymorphisms in oxidative stress-related genes (i.e., SOD2, CAT, GPX1, GSTM1, and GSTP1).
  • To assess whether these genetic polymorphisms are associated with progression-free survival and/or overall survival in these patients treated for lymphoma.

OUTLINE: Previously collected samples are used for biomarker analysis.


Study Type : Observational
Actual Enrollment : 337 participants
Time Perspective: Retrospective
Official Title: Pharmacogenomics of Oxidative Stress-Related Genes in Lymphoma
Study Start Date : April 2009
Actual Primary Completion Date : June 2014
Actual Study Completion Date : June 2014





Primary Outcome Measures :
  1. Association of polymorphisms in oxidative stress-related genes with overall survival and/or progression-free survival [ Time Frame: retrospectively ]
  2. Association of polymorphisms in these genes with rate of grade 4-5 hematologic toxicity [ Time Frame: retrospectively ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients enrolled on S8516 S8736 S9125 S9240 consenting to banking
Criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of aggressive B-cell non-Hodgkin lymphoma

    • Previously treated with curative intent using anthracycline-based therapies
  • Previously collected paraffin-embedded diagnostic tissues from clinical trials that were collected as part of SWOG treatment protocols (S8516, S8736, S9125, S9240, and S9349) available

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00985699


Sponsors and Collaborators
Southwest Oncology Group
National Cancer Institute (NCI)
Investigators
Study Chair: Margaret M. Briehl, PhD University of Arizona

Responsible Party: Southwest Oncology Group
ClinicalTrials.gov Identifier: NCT00985699     History of Changes
Other Study ID Numbers: CDR0000643248
SWOG-S8516-S8736-S9125-S9240-S ( Other Identifier: SWOG )
U10CA032102 ( U.S. NIH Grant/Contract )
First Posted: September 28, 2009    Key Record Dates
Last Update Posted: July 24, 2014
Last Verified: July 2014

Keywords provided by Southwest Oncology Group:
non-Hodgkin lymphoma
cutaneous B-cell non-Hodgkin lymphoma
extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
nodal marginal zone B-cell lymphoma

Additional relevant MeSH terms:
Lymphoma
Lymphoma, Non-Hodgkin
Lymphoma, B-Cell
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases