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Genetic Examination of Patients With Primary Multiple Hernia

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ClinicalTrials.gov Identifier: NCT00979095
Recruitment Status : Unknown
Verified October 2010 by Herlev Hospital.
Recruitment status was:  Recruiting
First Posted : September 17, 2009
Last Update Posted : October 13, 2010
Sponsor:
Information provided by:

Study Description
Brief Summary:

The investigators are performing a genetic study of patients with multiple hernias (at least 3 primary hernias) versus a healthy control group. This genetic information is compared with circulating and subcutaneously biomarkers such as matrix-metalloproteinases (MMP's).

The hypothesis is that patients with multiple hernias have different expression of specific genes compared to the healthy control group.


Condition or disease
Multiple Hernia

Detailed Description:

Other examinations performed on the patients enrolled in this study:

  • Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms.
  • Beightons score to evaluate the degree of joint hypermobility.

Study Design

Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Genetic Differences Between Patients With Multiple Hernia and a Healthy Control Group
Study Start Date : June 2009
Estimated Primary Completion Date : June 2011
Estimated Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hernia
U.S. FDA Resources

Groups and Cohorts

Group/Cohort
Multiple hernia
Patients with more than 3 primary hernias
Control group
Patients without hernias


Outcome Measures

Primary Outcome Measures :
  1. Genetic expression of relevant genes between the groups [ Time Frame: 12 months ]

Secondary Outcome Measures :
  1. Amount of serological biomarkers (MMP's) correlated to gene expression [ Time Frame: 12 months ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Danish citizens. Data have been retracted from The Danish Hernia Database.
Criteria

Inclusion Criteria:

  • Patients with minimum 3 primary hernias

Exclusion Criteria:

  • Patients under 18 years
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00979095


Locations
Denmark
Jacob Rosenberg Recruiting
Herlev Hospital, Herev, Denmark, 2730
Contact: Jakob Burcharth, MD    44884488 ext 89434    jakobburcharth@gmail.com   
Principal Investigator: Jakob Burcharth, MD         
Sponsors and Collaborators
Herlev Hospital
Investigators
Study Director: Jacob Rosenberg, Prof. MD Herlev Hospital
Principal Investigator: Jakob Burcharth, MD Herlev Hospital
More Information

Responsible Party: Jakob Burcharth, MD., Herlev Hospital
ClinicalTrials.gov Identifier: NCT00979095     History of Changes
Other Study ID Numbers: H-D-2008-126
First Posted: September 17, 2009    Key Record Dates
Last Update Posted: October 13, 2010
Last Verified: October 2010

Keywords provided by Herlev Hospital:
multiple hernia

Additional relevant MeSH terms:
Hernia
Pathological Conditions, Anatomical