Microenvironment of Adipose Tissue in Endocannabinoid System
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
The purpose of this study is examine the relationship between adipose tissue inflammation and activation of the endocannabinoid system before and after Roux-en-Y gastric bypass surgery. The investigators hypothesize that the metabolic improvements and weight loss are due to mechanisms that antagonize the endocannabinoid system.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
20 Years to 60 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Subjects approved and scheduled for gastric bypass surgery
Age 20-60 yrs
Approved and scheduled for gastric bypass surgery
Stable body weight for past 3 months
Positive pregnancy test
Previous gastric surgeries
History of ketoacidosis or current metabolic acidosis
Serum creatinine or liver function tests > 2 times upper limits of normal
Taking drugs that are known to affect carbohydrate or lipid metabolism other than anti-diabetes mediations.