Platelet Hyperreactivity Project (PHP)
This study has been completed.
Information provided by (Responsible Party):
Pierre Fontana, University Hospital, Geneva
First received: September 11, 2009
Last updated: December 1, 2015
Last verified: December 2015
The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients.
||Observational Model: Cohort
Time Perspective: Prospective
||Platelet Hyperreactivity Project: A System Biology Approach of High On-treatment Platelet Reactivity in Aspirin-treated Cardiovascular Patients
Primary Outcome Measures:
Secondary Outcome Measures:
- platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin [ Time Frame: cross sectional ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Other Outcome Measures:
- genetic polymorphisms associated with platelet hyperreactivity [ Time Frame: cross sectional ] [ Designated as safety issue: No ]
Plasma Serum Platelets
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||January 2010 (Final data collection date for primary outcome measure)
The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients using a system biology approach that include proteomics analysis of selected platelet sub-fractions in patients displaying extreme phenotype.
- to characterize the proteome profile of platelet hyperreactivity in aspirin-treated cardiovascular patients
- to characterize the platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin
- to determine genetic polymorphisms associated with platelet hyperreactivity
|Ages Eligible for Study:
||18 Years to 99 Years (Adult, Senior)
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Symptomatic atherothrombotic patients treated with aspirin.
- Documented symptomatic ischemic atherothrombotic disease treated by aspirin.
- Known platelet disorder
- Chronic treatment by antiplatelet drugs other than aspirin
- Chronic anticoagulant treatment
- Chronic non steroidal anti-inflammatory drug treatment
- Active cancer
- Treatment with serotonin reuptake inhibitors
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00976196
|University Hospital Geneva
|Geneva, Switzerland, 1205 |
||Pierre Fontana, MD, PhD
||University of Geneva
||Pierre Fontana, PI, University Hospital, Geneva
History of Changes
|Other Study ID Numbers:
|Study First Received:
||September 11, 2009
||December 1, 2015
||Switzerland: Federal Office of Public Health
Keywords provided by University Hospital, Geneva:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on December 05, 2016
Anti-Inflammatory Agents, Non-Steroidal
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Platelet Aggregation Inhibitors