Carotid Ultrasound Sub-Study of the Familial Atherosclerosis Study-observational Study (FATS)
This observational study looks at Carotid Stenosis in two groups of subjects using a non-invasive procedure, B-mode ultrasound.
One group of subjects has had long-term intensive lipid altering therapy (lowering LDL-C plus raising HDL-C). The second group of patients has been on conventional "standard of care" treatment for carotid stenosis.
The study will look at the Carotid Intima-media Thickness (CMIT) in both groups.
Hypothesis: CIMT will differ between the two groups, such that the CIMT will be less in the subjects on intensive lipid altering therapy.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Effects of Long-term Therapy With LDL-lowering Plus HDL Raising on Carotid Intima-media Thickness (CIMT) - Carotid Ultrasound Sub-Study of the Familial Atherosclerosis Study-observational Study|
- Carotid Intima-media Thickness [ Time Frame: Up to 3 years ] [ Designated as safety issue: No ]
|Study Start Date:||September 2006|
|Estimated Study Completion Date:||September 2011|
|Estimated Primary Completion Date:||September 2011 (Final data collection date for primary outcome measure)|
Intensive Lipid-lowering therapy
Subjects on intensive long-term lipid lowering therapy (lowering LDL-C plus raising of HDL-C).
Subjects with Atherosclerosis who have been on conventional "standard of care" treatment.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00976014
|United States, Washington|
|University of Washington|
|Seattle, Washington, United States, 98105|
|Principal Investigator:||Xue-Qiao Zhao||University of Washington|