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Psychophysiological Correlates of Mindfulness Based Cognitive Therapy (MBCT) in Recurrent Depression (MBCT & EEG)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Prof. Dr. Martin Hautzinger, University Hospital Tuebingen
ClinicalTrials.gov Identifier:
NCT00974077
First received: September 9, 2009
Last updated: December 19, 2014
Last verified: December 2014
  Purpose
The study investigates cognitive attention, rumination and psychophysiological (EEG) processes in healthy subjects and remitted patients with at least three previous depressive episodes. The investigators expect that Mindfulness Based Cognitive Therapy prevents future depressive episodes and has influence on cognitive and psychophysiological measures.

Condition Intervention
Depression
Behavioral: Mindfulness Based Cognitive Therapy
Other: Waiting List Control

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Psychophysiological Correlates of Mindfulness and Attention in Recurrent Depression and Healthy Volunteers

Further study details as provided by University Hospital Tuebingen:

Primary Outcome Measures:
  • Relapse (MDE) [ Time Frame: 12 month ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Electroencephalography (EEG) [ Time Frame: 6 month ] [ Designated as safety issue: No ]

Enrollment: 120
Study Start Date: September 2008
Study Completion Date: July 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Wait List Control
Patients do ot receive psychotherapy. The wait list control group will be assessed according to study protocol and offered MBCT after 6 month
Other: Waiting List Control
Patients receive MBCT with a delay of 6 months.
Experimental: Mindfulness Based Cognitive Therapy
The published protocol of MBCT will be used. This is an eight week group program. Participants learn mindfulness techniques but also cognitive techniques to prevent new depressive episodes
Behavioral: Mindfulness Based Cognitive Therapy
Group treatment over 8 weeks with training in meditation, stress regulation, shift attention, stay present, in addition with cognitive and behavioral strategies (following Williams et al. Manual 2002)

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • recurrent depression with at least 3 previous MD-episodes, currently remitted (no symptoms)

Exclusion Criteria:

  • current depression
  • lifetime schizophrenia
  • bipolar or schizoaffective disorder
  • any neurological disorders
  • other psychopathology during last 3 years
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00974077

Locations
Germany
Department of Psychology University of Tuebingen
Tuebingen, Germany, D-72072
Sponsors and Collaborators
University Hospital Tuebingen
Investigators
Principal Investigator: Martin Hautzinger, PhD Eberhard Karls University
  More Information

Publications:
Responsible Party: Prof. Dr. Martin Hautzinger, University Professor of Clinical Psychology and Psychotherapy, University Hospital Tuebingen
ClinicalTrials.gov Identifier: NCT00974077     History of Changes
Other Study ID Numbers: HA1399/16-1 
Study First Received: September 9, 2009
Last Updated: December 19, 2014
Health Authority: Germany: Ethics Commission

Keywords provided by University Hospital Tuebingen:
recurrent depression,
mindfulness training
attention
Evoked EEG potentials
Relapse prevention in recurrent depression

Additional relevant MeSH terms:
Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on December 05, 2016