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Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infections

This study has been completed.
Finnish Defense Forces
Information provided by (Responsible Party):
Ilkka Laaksi, University of Tampere Identifier:
First received: September 8, 2009
Last updated: December 2, 2014
Last verified: December 2014
The investigators earlier clinical study in 754 young Finnish men demonstrated a significant negative association of serum 25-OHD concentration with acute respiratory tract infections. The present study aimed to determine whether vitamin D supplementation may decrease the incidence of acute respiratory tract infections.

Condition Intervention
Respiratory Tract Infections Dietary Supplement: vitamin D Dietary Supplement: placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infections; a Randomized Double-blinded Trial in Young Finnish Men

Resource links provided by NLM:

Further study details as provided by Ilkka Laaksi, University of Tampere:

Primary Outcome Measures:
  • Number of days absent from duty due to respiratory tract infection [ Time Frame: 6 months ]

Secondary Outcome Measures:
  • The proportion of men remaining healthy throughout the 6-month study period [ Time Frame: 6 months ]
  • The number needed to treat calculated from the proportion of men without any days absent from duty [ Time Frame: 6 months ]

Enrollment: 164
Study Start Date: May 2005
Study Completion Date: December 2010
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: vitamin D Dietary Supplement: vitamin D
vitamin D3 400 IU daily
Other Name: Minisun
Placebo Comparator: placebo Dietary Supplement: placebo
Other Name: Pharmia, Finland

Detailed Description:
Subjects comprised 164 male conscripts at a military base in Finland. Half of the participants were randomly allocated to receive 400 IU vitamin D daily and half received placebo from October through March. Serum vitamin D and plasma parathyroid hormone concentrations were determined. Subjects were followed for 6 months and the primary outcome was the number of days absent from duty due to ARTI.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

Exclusion Criteria:

  • Use vitamin D
  Contacts and Locations
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Please refer to this study by its identifier: NCT00973583

university of Tampere
Tampere, Finland, 33014
Sponsors and Collaborators
University of Tampere
Finnish Defense Forces
Principal Investigator: Ilkka T Laaksi, M.D. University of Tampere
Study Director: Harri Pihlajamaki, Docent Research Department, Centre for Military Medicine, Helsinki, Finland
  More Information

Responsible Party: Ilkka Laaksi, M.D. PhD, University of Tampere Identifier: NCT00973583     History of Changes
Other Study ID Numbers: UTampere-RO5125
Study First Received: September 8, 2009
Last Updated: December 2, 2014

Keywords provided by Ilkka Laaksi, University of Tampere:
vitamin D
Vitamin D for the prevention of respiratory tract infections

Additional relevant MeSH terms:
Communicable Diseases
Respiratory Tract Infections
Respiratory Tract Diseases
Vitamin D
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents processed this record on August 18, 2017