Intra-articular Glucocorticoid Treatment of the Elbow
BACKGROUND: Intra-articular glucocorticoid injections are frequently used to relieve symptoms of arthritis. Postinjection rest has been shown to improve the outcome of knee joint injections, but not for wrist injections. Consequently, different joints respond differently on postinjection regimens.
OBJECTIVES: To investigate whether better treatment results might be achieved of post-injection rest following intra-articular glucocorticoid treatment for elbow synovitis.
METHODS: 90 patients with rheumatoid arthritis (RA) and elbow synovitis were treated with 20 mg intra-articular triamcinolone hexacetonide and randomised to either a 48 hour immobilisation in a triangular sling (n=46) or normal activity without restrictions (n=44). Primary endpoint was relapse of synovitis. In addition, pain, function according to a self assessment questionnaire (PREE) and range of movement were followed for six months.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||The Importance of Immobilisation After Intra-articular Glucocorticoid Treatment for Elbow Synovitis - a Randomised and Controlled Study|
- Relapse of Arthritis [ Time Frame: Regular visits at one week, 3 months and 6 months. ] [ Designated as safety issue: No ]
|Study Start Date:||January 2006|
|Study Completion Date:||December 2008|
|Primary Completion Date:||December 2008 (Final data collection date for primary outcome measure)|
No Intervention: Activity
Normal activity without restrictions
Active Comparator: immobilisation
48 hours postinjection rest
Behavioral: immobilisation in a triangular sling
Intervention group: Immobilisation 48 hours in a triangular sling (mitella)
Control group: normal activity without restrictions
Please refer to this study by its ClinicalTrials.gov identifier: NCT00972530
|Principal Investigator:||Tomas Weitoft, MD PhD||Department of Research and Development County Council of Gävleborg/Uppsala University|