Stability of Motor Output in Aging Adults
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|ClinicalTrials.gov Identifier: NCT00970736|
Recruitment Status : Completed
First Posted : September 2, 2009
Results First Posted : April 8, 2015
Last Update Posted : April 8, 2015
|Condition or disease|
A large number of our nation's veterans develop dysphagia due to the myriad of potential etiological sources of swallowing disorders, including stroke and head and neck cancer. The Veteran's Health Administration has recently identified dysphagia as a major clinical focus for the VA system (Sullivan & Dennis, 2006). In order to accurately assess adaptations in motor cortex, it is first necessary to have a reliable tool for measuring organizational representation in the motor cortex. Transcranial magnetic stimulation (TMS) is a desirable choice for such measurement because of the ability to identify causative relationships between an area of motor cortex stimulated and muscle response. Therefore, the specific research objectives of this proposal are:
- To demonstrate the reproducibility of TMS mapping of the submental muscle group in healthy older adults between 60 and 80 years of age
- To determine the neural representation of submental musculature in the motor cortex of healthy older adults between 60 and 80 years of age.
Twenty healthy adults, 10 men and 10 women, between the ages of 60 and 80 years will serve as research participants. TMS will be used to establish motor maps of the submental muscles. Subjects will undergo two testing sessions, on day 1 and day 14. The results from each session will be compared to assess excitability and representation within the motor cortex, and to assess stability and reliability of measurement.
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||Corticobulbar Motor Output in Aging Adults|
|Study Start Date :||November 2009|
|Primary Completion Date :||October 2011|
|Study Completion Date :||October 2011|
20 healthy participants between 60 and 80 years of age. Ten men and 10 women.
- Mean Motor Evoked Potential Amplitude for Submental Cortical Representation [ Time Frame: 2 weeks ]Cortical sites are stimulated sequentially from the SOLMT in the anterior direction. At each site, 5 pulses of 110% of the MEP threshold obtained at the SOLMT are delivered and recorded. If a site produces no MEP in 3/5 pulses it is considered non-submental. This process is continued until the entire submental representation is surrounded by non-submental responsive sites. The number of sites is used to calculate the area of submental representation. The mean sEMG amplitudes of the submental muscles for each of these sites is then calculated for the mean MEP measure.
- Motor Map Center of Gravity [ Time Frame: 2 weeks ]Position on the TMS motor map with highest amplitude response to stimulation in the muscles of interest (submental muscles).
- Area of Submental Representation [ Time Frame: 2 weeks ]Cortical sites are stimulated sequentially from the SOLMT in the anterior direction. At each site, 5 pulses of 110% of the MEP threshold obtained at the SOLMT are delivered and recorded. If a site produces no MEP in 3/5 pulses it is considered non-submental. This process is continued until the entire submental representation is surrounded by non-submental responsive sites. The number of sites is used to calculate the area of submental representation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00970736
|United States, Florida|
|North Florida/South Georgia Veterans Health System|
|Gainesville, Florida, United States, 32608|
|Principal Investigator:||Karen Hegland, PhD||North Florida/South Georgia Veterans Health System|