Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Dexamethasone and Etoricoxib for Pain Prevention Following Periodontal Surgery

This study has been completed.
Information provided by:
Universidade Estadual de Ponta Grossa Identifier:
First received: August 31, 2009
Last updated: May 17, 2010
Last verified: March 2010
The purpose of this study is to investigate whether preemptive medication with dexamethasone or etoricoxib provides better pain management and control than placebo following periodontal surgery.

Condition Intervention Phase
Pain Control
Procedure: Open Flap Debridement
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: O Uso de Dexametasona e Etoricoxibe Para a prevenção e Controle da Dor pós-operatória após Cirurgia Periodontal

Further study details as provided by Universidade Estadual de Ponta Grossa:

Primary Outcome Measures:
  • pain [ Time Frame: up to 3 days ]
    hourly for the 8 first hours after surgery 3 times a day on the following 3 days

Enrollment: 20
Study Start Date: November 2008
Study Completion Date: March 2010
Primary Completion Date: September 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: Placebo
Placebo 1 hour before surgery
Procedure: Open Flap Debridement
Open flap debridement - access flap + scaling and root planning
Experimental: Etoricoxib
Etoricoxib 1 hour before surgery
Procedure: Open Flap Debridement
Open flap debridement - access flap + scaling and root planning
Experimental: Dexamethaone
Dexamethasone 1 hour before surgery
Procedure: Open Flap Debridement
Open flap debridement - access flap + scaling and root planning


Ages Eligible for Study:   20 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Patients presenting moderate or severe periodontitis after nonsurgical periodontal treatment with clinical signs of inflammation

Exclusion Criteria:

  • Pregnant
  • Diabetes mellitus
  • Heart diseases
  • Allergic to components of the medications
  • Risk of endocarditis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00970112

Ponta Grossa, Paraná, Brazil
Sponsors and Collaborators
Universidade Estadual de Ponta Grossa
Principal Investigator: João Paulo Steffens, MSc Student UEPG
Study Director: Fábio André Santos, PhD UEPG
Study Chair: Gibson Luiz Pilatti, PhD UEPG
  More Information

Responsible Party: Gibson Luiz Pilatti, UEPG Identifier: NCT00970112     History of Changes
Other Study ID Numbers: 08169/08
Study First Received: August 31, 2009
Last Updated: May 17, 2010

Keywords provided by Universidade Estadual de Ponta Grossa:
pain assessment

Additional relevant MeSH terms:
Anti-Inflammatory Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Gastrointestinal Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Antirheumatic Agents processed this record on May 25, 2017