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Exercise and Nerve Function in Diabetes

This study has been completed.
Information provided by (Responsible Party):
Patricia Kluding, PhD, University of Kansas Medical Center Research Institute Identifier:
First received: September 1, 2009
Last updated: July 3, 2013
Last verified: July 2013
The purpose of this study is to describe the effect of a 10-week exercise program on nerve function and number of nerve fibers in the skin in the lower leg in people with diabetic neuropathy.

Condition Intervention
Diabetic Neuropathy
Behavioral: Exercise

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: Effectiveness of an Exercise Program on Nerve Function and Cutaneous Nerve Fibers in Adults With Type 2 Diabetes

Resource links provided by NLM:

Further study details as provided by University of Kansas Medical Center:

Primary Outcome Measures:
  • Quantitative sensory testing [ Time Frame: 10 weeks ]
  • Nerve conduction studies [ Time Frame: 10 weeks ]
  • Proprioception [ Time Frame: 10 weeks ]
  • Dermal and epidermal nerve fiber densities [ Time Frame: 10 weeks ]

Secondary Outcome Measures:
  • Clinical assessments of neuropathy, pain, body mass index, muscle strength, and glycemic control (glycosylated hemoglobin or A1C) [ Time Frame: 10 weeks ]

Enrollment: 26
Study Start Date: June 2008
Study Completion Date: October 2009
Primary Completion Date: October 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise program
Supervised moderately-intense exercise, including both aerobic and strengthening activities. Sessions are 3-4 days per week for 10 weeks.
Behavioral: Exercise
Supervised moderately-intense exercise, including both aerobic and strengthening activities. Sessions are 3-4 days per week for 10 weeks.

Detailed Description:
The objective for this application is to quantify the benefits of exercise on nerve function including proprioception, and investigate the relationship of these findings with improvements in epidermal and dermal innervation. In this pilot project, we will pursue 2 specific aims: 1) determine the effect of an exercise intervention on nerve function in people with diabetic neuropathy, and 2) assess changes in cutaneous innervation following participation in an exercise program.

Ages Eligible for Study:   40 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 40-70
  • Type 2 diabetes
  • Peripheral neuropathy

Exclusion Criteria:

  • Serious cardiac history or other medical problems that would prevent safe participation in exercise
  Contacts and Locations
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Please refer to this study by its identifier: NCT00970060

United States, Kansas
Patricia Kluding PhD
Kansas City, Kansas, United States, 66160
Sponsors and Collaborators
Patricia Kluding, PhD
Principal Investigator: Patricia Kluding, PhD University of Kansas Medical Center
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Patricia Kluding, PhD, Associate Professor, University of Kansas Medical Center Research Institute Identifier: NCT00970060     History of Changes
Other Study ID Numbers: 11385
GCRC #105 ( Other Identifier: Clinical and Translational Science Unit )
Study First Received: September 1, 2009
Last Updated: July 3, 2013

Keywords provided by University of Kansas Medical Center:

Additional relevant MeSH terms:
Diabetic Neuropathies
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nervous System Diseases
Diabetes Complications
Diabetes Mellitus
Endocrine System Diseases processed this record on April 28, 2017