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The Effect of Periodontal Treatment on the Level of Free Radicals in the Saliva

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2009 by The Baruch Padeh Medical Center, Poriya.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00969241
First Posted: September 1, 2009
Last Update Posted: December 23, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
The Baruch Padeh Medical Center, Poriya
  Purpose
This study will examine the relationship between free radicals in the saliva and periodontitis. 30 adults, 15 with periodontitis and 15 as a control group will give a sample of saliva before treatment and after treatment. The investigators will examine the free radicals in both groups.

Condition
Periodontitis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Effect of Periodontal Treatment on the Level of Free Radicals in the Saliva

Further study details as provided by The Baruch Padeh Medical Center, Poriya:

Estimated Enrollment: 30
Study Start Date: July 2009
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Detailed Description:

Periodontal disease is a chronic adult condition. Bacteria implicated in the etiology of this disease causes destruction of connective tissue and bone. As a result of stimulation by bacterial antigen PMN produces free radicals via respiratory burst as a part of host response to infection.

Free radicals can be defined as molecules or molecular fragments with an unpaired electron which imparts certain characteristics to the free radicals such as reactivity . Reactive free radicals are able to produce chemical modifications and to damage proteins, lipids, carbohydrates and nucleotides in the tissues.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with periodontitis who visit the department and volunteers.
Criteria

Inclusion Criteria:

  • older than 18
  • no medical problems

Exclusion Criteria:

  • medical problems
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00969241


Locations
Israel
department of oral and maxillofacial surgery, Baruch Padeh Medical Center Recruiting
Tieberia, Israel, Poria, Israel
Contact: Eran Front, Dr. DMD    972-046652254    efront@bezeqint.net   
Contact: reem younis, Dr.    972-54- 4860977    younis.reem@gmail.com   
Principal Investigator: Eran Front, Dr.         
Sub-Investigator: Tsvika laster, Dr. DMD         
Sub-Investigator: REEM YOUNIS, DMD         
Sponsors and Collaborators
The Baruch Padeh Medical Center, Poriya
Investigators
Principal Investigator: eran front, Dr. department of oral and maxillofacial surgery
  More Information

Responsible Party: Dr. front the department of oral and maxillofacial surgery, the department of oral and maxillofacial surgery - poria madical center
ClinicalTrials.gov Identifier: NCT00969241     History of Changes
Other Study ID Numbers: 920090018-YR.ctil
First Submitted: August 30, 2009
First Posted: September 1, 2009
Last Update Posted: December 23, 2010
Last Verified: August 2009

Keywords provided by The Baruch Padeh Medical Center, Poriya:
saliva
free-radicals
periodontitis

Additional relevant MeSH terms:
Periodontitis
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases


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