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Milrinone During Living Donor Hepatectomy

This study has been completed.
Information provided by:
Seoul National University Hospital Identifier:
First received: August 13, 2009
Last updated: August 26, 2009
Last verified: August 2009
Maintaining a low central venous pressure during living donor hepatectomy is routine practice. The investigators tried to test the hypothesis that using milrinone to maintain a low central venous pressure (CVP) during is associated with a superior surgical field and less blood loss.

Condition Intervention
Drug: milrinone
Drug: placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: Effect of Milrinone During Living Donor Hepatectomy Using a Low Central Venous Pressure Technique

Resource links provided by NLM:

Further study details as provided by Seoul National University Hospital:

Primary Outcome Measures:
  • condition of surgical field [ Time Frame: intraoperative period (from the start of surgery to end of living donor hepatectomy) ]

Secondary Outcome Measures:
  • the use of vasopressor and diuretics to maintain hemodynamic stability and low CVP status, respectively [ Time Frame: intraoperative period (from the start of surgery to end of living donor hepatectomy) ]

Enrollment: 38
Study Start Date: January 2008
Study Completion Date: December 2008
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: milrinone
milrinone infusion
Drug: milrinone
Placebo Comparator: placebo Drug: placebo


Ages Eligible for Study:   19 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Living liver donors

Exclusion Criteria:

  • Donors with concurrent cardiac, pulmonary, and urologic disease
  • Hepatectomy performed laparoscopically
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Please refer to this study by its identifier: NCT00966745

Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of, 110-744
Sponsors and Collaborators
Seoul National University Hospital
  More Information Identifier: NCT00966745     History of Changes
Other Study ID Numbers: mil_living_liver_donor
Study First Received: August 13, 2009
Last Updated: August 26, 2009

Keywords provided by Seoul National University Hospital:
surgical field condition

Additional relevant MeSH terms:
Cardiotonic Agents
Platelet Aggregation Inhibitors
Vasodilator Agents
Phosphodiesterase 3 Inhibitors
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs processed this record on May 25, 2017