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Ghrelin, Growth Hormone and Growth Factors at High Altitude

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ClinicalTrials.gov Identifier: NCT00966134
Recruitment Status : Completed
First Posted : August 26, 2009
Last Update Posted : February 23, 2010
Sponsor:
Information provided by:
Medical University of Vienna

Brief Summary:

Regulation of ghrelin, growth hormone and growth factors at high altitude and their change during ascent to high altitude has not been studied in depth yet. The study includes 33 volunteers (12f) investigated at sea level, 4 days after ascent to 3440m and 14 days after ascent to 5400-5900m.

The investigators hypothesized that during ascent growth hormone levels would increase to compensate for the higher energy needs at high altitude.


Condition or disease Intervention/treatment
Healthy Growth Hormone Other: exposure to high altitude

Study Type : Observational
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : April 2002
Actual Study Completion Date : September 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hormones
U.S. FDA Resources

Group/Cohort Intervention/treatment
probands Other: exposure to high altitude



Primary Outcome Measures :
  1. Ghrelin, growth hormone, insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP1), IGF binding protein 2 (IGFBP2), IGF binding protein 3 (IGFBP3), acid-labile subunit (ALS), insulin, prolactin [ Time Frame: 14 days ]


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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy Caucasians from an Alpinist association
Criteria

Inclusion Criteria:

  • Healthy and good physical fitness

Responsible Party: Prof Herwig Frisch, Pediatric Department
ClinicalTrials.gov Identifier: NCT00966134     History of Changes
Other Study ID Numbers: EK 411
First Posted: August 26, 2009    Key Record Dates
Last Update Posted: February 23, 2010
Last Verified: August 2009

Keywords provided by Medical University of Vienna:
mountain medicine
ghrelin
growth hormone
hypoxia
physiology of hormonal adaptation to high altitude