The Comparison of Oxidative Stress Between Inhalation Anesthetics
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||The Comparison of Oxidative Stress Between Inhalation Anesthetics|
- isoprostanes isomer as marker of oxidative stress [ Time Frame: one day ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||March 2007|
|Study Completion Date:||December 2007|
|Primary Completion Date:||December 2007 (Final data collection date for primary outcome measure)|
|cardiac surgery with CPB|
Enhanced production of oxygen free radicals can lead to the generation of oxidative stress, which is harmful to human tissue and organs. Reactive oxygen species are released abruptly during some surgical procedures, and they are the major causes of ischemia-reperfusion injuries.Isoprostanes have been demonstrated to be a reliable biomarker for the evaluation of oxidative stress in vivo. Therefore, accurately monitoring and avoiding the occurrence of oxidative stress during surgery is an important clinical issue.
Isoprostanes are a series of prostaglandin-like compounds produced by non-enzymatic peroxidation of arachidonic acid.The aims of this study are(1)to develop an accurate liquid chromatography-tandem mass spectrometry methods for the detection of urinary isoprostane isomers in samples collected from patients receiving a cardiac surgery (2)to investigate the change of isoprostanes after cardiopulmonary bypass (3)to investigate the effect of different anesthetics on isoprostanes during surgery.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00965445
|Dept. of Anesthesiology, Chang Gung Memorial Hospital|
|Taipei, Taiwan, 105|
|Principal Investigator:||Yun-Hui Teng, MD||Chang Gung Memorial Hospital|