Mechanisms of Severe Acute Influenza Consortium (MOSAIC) (MOSAIC)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00965354
Recruitment Status : Completed
First Posted : August 25, 2009
Last Update Posted : June 8, 2015
Wellcome Trust
Medical Research Council
Information provided by (Responsible Party):
Imperial College London

Brief Summary:

Influenza A is one of the best studied viruses, but continues to have a very large impact on human and animal health. In addition to causing outbreaks of winter flu, it sometimes mutates to create a new virus that spreads quickly around the world. It is puzzling that the same virus appears to cause minor or absent symptoms in some people while killing others. Much remains to be understood.

We have assembled an unprecedented group of internationally renowned scientists from England and Scotland who will together focus on studying a few hundred people hospitalised during the current swine flu pandemic. Such a largescale project has never before been attempted, but we are now poised to work together and integrate the many recent advances in biomedical science that relate to understanding how influenza causes disease.

The ultimate goal of this collaborative, intensive study is to discover new and effective treatments and to develop better vaccines that can be used in future outbreaks. By integrating the information that we will gather, we will create a unique overview of how influenza causes illness and what might be done to improve patient management.

Condition or disease

Study Type : Observational
Actual Enrollment : 257 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Mechanisms of Severe Acute Influenza Consortium (MOSAIC)
Study Start Date : December 2009
Actual Primary Completion Date : February 2011
Actual Study Completion Date : February 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Flu Flu Shot

Influenza diagnosis
Patients admitted to hospital with a suspected or confirmed influenza diagnosis on admission

Primary Outcome Measures :
  1. Detailed clinical phenotype. Clinicopathological correlation will then be sought between the clinical phenotype and pathological parameters measured as per work packages. [ Time Frame: 3 years ]

Secondary Outcome Measures :
  1. Response to drug treatment and the effect of drug resistance if that emerges. [ Time Frame: 3 years ]

Biospecimen Retention:   Samples With DNA

A) Swabs and secretions from the nose and throat B) Blood C) Sputum D) Urine E) Stool

In addition, if the patients are having further respiratory sample collection as part of their routine care, for example tracheal aspirates, bronchial lavage and other samples then we would like to take an additional amount of these samples for our research.

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Hospital admissions

Inclusion Criteria:

  • Any patient admitted to hospital with suspected or confirmed influenza infection

Exclusion Criteria:

  • Patients who do not give their consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00965354

United Kingdom
Alder Hey Children's Foundation NHS Trust
Liverpool, United Kingdom, L12 2AP
Royal Liverpool University Hospital
Liverpool, United Kingdom, L7 8XP
Liverpool Women's NHS Foundation Trust
Liverpool, United Kingdom, L8 7SS
Aintree Hospitals NHS Trust
Liverpool, United Kingdom, L9 7AL
Chelsea and Westminster Hospital NHS Foundation Trust
London, United Kingdom, SW10 9NH
Royal Brompton and Harefield NHS Foundation Trust
London, United Kingdom, SW3 6NP
Imperial College Healthcare NHS Trust
London, United Kingdom, W2 1PG
Wirral University Teaching Hospital NHS Foundation Trust
Wirral, United Kingdom, CH49 5PE
Sponsors and Collaborators
Imperial College London
Wellcome Trust
Medical Research Council
Principal Investigator: Peter JM Openshaw Imperial College London

Responsible Party: Imperial College London Identifier: NCT00965354     History of Changes
Other Study ID Numbers: CRO1367
09/H0709/52 ( Other Identifier: English Research Ethics Committee )
09/MRE00/67 ( Other Identifier: Scottish Research Ethics Committee )
First Posted: August 25, 2009    Key Record Dates
Last Update Posted: June 8, 2015
Last Verified: June 2011

Keywords provided by Imperial College London:
influenza A

Additional relevant MeSH terms:
Influenza, Human
Orthomyxoviridae Infections
RNA Virus Infections
Virus Diseases
Respiratory Tract Infections
Respiratory Tract Diseases