Diagnostic Usefulness of Interferon Gamma Release Assay for Active Tuberculosis in Immunocompromised Patients

This study has been completed.
Information provided by (Responsible Party):
Yonsei University
ClinicalTrials.gov Identifier:
First received: August 19, 2009
Last updated: January 31, 2012
Last verified: January 2012
For diagnosis of active tuberculosis, interferon-γ release assay based mycobacterium tuberculosis specific antigen may show higher sensitivity than tuberculin skin test in immunocompromised patients. Therefore, interferon-γ release assay have a role as a rapid diagnostic adjunctive methods for active tuberculosis in immunocompromised patients.


Study Type: Observational

Resource links provided by NLM:

Further study details as provided by Yonsei University:

Enrollment: 140
Study Start Date: July 2009
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
immunocompromised group
non-immunocompromised group


Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
suspicious of tuberculosis, immunocompromised patients such cancer patients on chemotherapy, transplantation patients, patients with immunosuppressant

Inclusion Criteria:

  • Patient suspicious of active tuberculosis with immunocompromised condition
  • Immunocompromised condition patients with

    1. solid cancer with chemotherapy
    2. hematologic malignancy
    3. organ transplantation
    4. immunosuppressant
    5. ESRD on renal replacement therapy
    6. diabetes
    7. advanced liver cirrhosis

Exclusion Criteria:

  • Patients with

    1. less than 20 years
    2. who don't agree the participation of study
    3. hypersensitivity history to tuberculin
    4. pregnancy
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00962676

Korea, Republic of
Yonsei Univ.
Seoul, Korea, Republic of
Sponsors and Collaborators
Yonsei University
  More Information

No publications provided

Responsible Party: Yonsei University
ClinicalTrials.gov Identifier: NCT00962676     History of Changes
Other Study ID Numbers: 4-2009-0129 
Study First Received: August 19, 2009
Last Updated: January 31, 2012
Health Authority: Korea: Food and Drug Administration
Korea: Ministry for Health and Welfare

Keywords provided by Yonsei University:
suspicious of tuberculosis
immunocompromised patients

Additional relevant MeSH terms:
Actinomycetales Infections
Bacterial Infections
Gram-Positive Bacterial Infections
Mycobacterium Infections

ClinicalTrials.gov processed this record on February 04, 2016