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Computed Tomographic (CT) Perfusion and CT Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00962546
First Posted: August 20, 2009
Last Update Posted: December 9, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Michelle Miller-Thomas, MD, Washington University School of Medicine
  Purpose
Cerebral vasospasm is a devastating complication of subarachnoid hemorrhage after cerebral aneurysm rupture leading to cerebral ischemia and potentially cerebral infarction. The current gold standard diagnostic imaging study for cerebral vasospasm is catheter cerebral angiography, an invasive diagnostic procedure carrying a complication rate of 1-2% per procedure. Computed tomographic perfusion imaging (CTP) and computed tomographic angiography (CTA) are noninvasive diagnostic imaging studies frequently utilized in the evaluation of embolic and thrombotic cerebral infarct. The investigators hypothesize that CTP and CTA may be utilized as screening tools for cerebral vasospasm following aneurysmal subarachnoid hemorrhage requiring treatment and provide prognostic information.

Condition
Cerebral Vasospasm Cerebral Aneurysm Subarachnoid Hemorrhage

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Computed Tomographic Perfusion and Computed Tomographic Angiography as Screening Tools for Vasospasm Following Subarachnoid Hemorrhage

Resource links provided by NLM:


Further study details as provided by Michelle Miller-Thomas, MD, Washington University School of Medicine:

Primary Outcome Measures:
  • CT perfusion parameters [ Time Frame: at time of catheter angiogram ]

Secondary Outcome Measures:
  • Disposition at discharge [ Time Frame: At time of hospital discharge ]
  • vessel narrowing by CT angiography [ Time Frame: at time of catheter angiogram ]

Enrollment: 4
Study Start Date: September 2009
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
CTA/CTP
Patients undergo CTA/CTP imaging prior to cerebral angiography

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients admitted to the neurological intensive care unit with subarachnoid hemorrhage due to rupture of a cerebral aneurysm
Criteria

Inclusion Criteria:

  • subarachnoid hemorrhage after aneurysm rupture

Exclusion Criteria:

  • renal insufficiency
  • pregnancy
  • contrast reaction
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00962546


Locations
United States, Missouri
Barnes-Jewish Hospital
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University School of Medicine
Investigators
Principal Investigator: Michelle Miller-Thomas, MD Washington University School of Medicine
  More Information

Publications:
Responsible Party: Michelle Miller-Thomas, MD, Assistant Professor, Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT00962546     History of Changes
Other Study ID Numbers: HRPO 09-0950
First Submitted: August 19, 2009
First Posted: August 20, 2009
Last Update Posted: December 9, 2014
Last Verified: December 2014

Keywords provided by Michelle Miller-Thomas, MD, Washington University School of Medicine:
cerebral aneurysm
subarachnoid hemorrhage
cerebral vasospasm
computed tomographic perfusion
computed tomographic angiography

Additional relevant MeSH terms:
Hemorrhage
Aneurysm
Subarachnoid Hemorrhage
Intracranial Aneurysm
Vasospasm, Intracranial
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Intracranial Hemorrhages
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Intracranial Arterial Diseases