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Pulmonary Hypertension in Lymphangioleiomyomatosis (LAM-PH)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00960895
Recruitment Status : Completed
First Posted : August 18, 2009
Last Update Posted : October 27, 2011
Sponsor:
Collaborator:
Hospices Civils de Lyon
Information provided by (Responsible Party):
Vincent COTTIN, Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires

Brief Summary:
This is a descriptive study of patients with Lymphangioleiomyomatosis and precapillary pulmonary hypertension.

Condition or disease
Lymphangioleiomyomatosis Pulmonary Hypertension

Detailed Description:
Descriptive study of patients with Lymphangioleiomyomatosis and precapillary pulmonary hypertension This will include modality of diagnosis of lLymphangioleiomyomatosis, results of right-sided heart catheterization, and pulmonary function tests

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Study Type : Observational
Actual Enrollment : 20 participants
Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Observational Study of Patients With Lymphangioleiomyomatosis and Pulmonary Hypertension
Study Start Date : August 2009
Actual Primary Completion Date : December 2009
Actual Study Completion Date : December 2010






Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Lymphangioleiomyomatosis, either sporadic or associated with tuberous sclerosis Precapillary pulmonary hypertension, as defined by right-sided heart catheterization (mean pulmonary artery pressure higher than 25 mmHg, wedge capillary pulmonary pressure less than 15 mmHg, pulmonary vascular resistance higher than 3 Wood units)
Criteria

Inclusion Criteria:

  • Lymphangioleiomyomatosis (definite or probable), either sporadic or associated with tuberous sclerosis
  • Precapillary pulmonary hypertension, as defined by right-sided heart catheterization (mean pulmonary artery pressure higher than 25 mmHg, wedge capillary pulmonary pressure less than 15 mmHg, pulmonary vascular resistance higher than 3 Wood units)

Exclusion Criteria:

  • Post capillary pulmonary hypertension
  • Other identifiable causes of pulmonary hypertension (ex: thromboembolic disease)
  • Not willing to participate

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00960895


Locations
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France
Louis Pradel Hospital
Lyon, University of Lyon, France, 69677
Sponsors and Collaborators
Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires
Hospices Civils de Lyon
Investigators
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Principal Investigator: Vincent Cottin, MD University of Lyon
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Responsible Party: Vincent COTTIN, Pr Cottin, Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires, Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires
ClinicalTrials.gov Identifier: NCT00960895    
Other Study ID Numbers: GERMOP-001
First Posted: August 18, 2009    Key Record Dates
Last Update Posted: October 27, 2011
Last Verified: October 2011
Keywords provided by Vincent COTTIN, Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires:
Lymphangioleiomyomatosis
Pulmonary hypertension
Additional relevant MeSH terms:
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Lymphangioleiomyomatosis
Hypertension, Pulmonary
Hypertension
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases
Lymphangiomyoma
Lymphatic Vessel Tumors
Neoplasms by Histologic Type
Neoplasms
Perivascular Epithelioid Cell Neoplasms
Neoplasms, Connective and Soft Tissue
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases