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"Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up

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ClinicalTrials.gov Identifier: NCT00960817
Recruitment Status : Unknown
Verified August 2009 by Hillel Yaffe Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : August 18, 2009
Last Update Posted : August 18, 2009
Sponsor:
Information provided by:

Study Description
Brief Summary:
The investigators will investigate patients undergoing coronary angiography with normal coronary but slow blood flow that was normalized after adenosine injection into the coronary artery. The investigators believe that they have small vessel coronary disease which is the initial presentation of coronary disease prior to anatomical narrowing. To alleviate this phenomenon the investigators intend to examine the long-term clinical response of these patients to treatment with dipyridamole, a well-known medication with almost no side-effects that increases the level of adenosine in the tissue.

Condition or disease Intervention/treatment Phase
Coronary Angiography Drug: Statin, aspirin Drug: Dipyridamole Early Phase 1

Study Design

Study Type : Interventional  (Clinical Trial)
Official Title: "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Active Comparator: 1. Routine treatment
Control group
Drug: Statin, aspirin
Experimental: 2. Dipyridamole treatment
Group that receives Dipyridamole treatment
Drug: Dipyridamole


Outcome Measures

Primary Outcome Measures :
  1. Alleviation of chest pain [ Time Frame: Two years ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients undergoing coronary angiography and who have normal coronary artery with slow blood flow that normalized with adenosine injection into the coronary artery

Exclusion Criteria:

  • Significant coronary disease
  • Unstable patients
  • Patients with known sensitivity to dipyridamole
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00960817


Locations
Israel
Hillel Yaffe Medical Center Not yet recruiting
Hadera, Israel, 38100
Principal Investigator: Aaron Frimerman, MD         
Sponsors and Collaborators
Hillel Yaffe Medical Center
More Information

Responsible Party: Aaron Frimerman, MD, Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier: NCT00960817     History of Changes
Other Study ID Numbers: HYMC 02/2009
First Posted: August 18, 2009    Key Record Dates
Last Update Posted: August 18, 2009
Last Verified: August 2009

Keywords provided by Hillel Yaffe Medical Center:
Normal coronary artery with slow blood flow

Additional relevant MeSH terms:
Adenosine
Dipyridamole
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Arrhythmia Agents
Vasodilator Agents
Purinergic P1 Receptor Agonists
Purinergic Agonists
Purinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Platelet Aggregation Inhibitors