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Biomarkers of the Response to Osteopathic Manipulation

This study has been completed.
American Osteopathic Association
Information provided by:
West Virginia School of Osteopathic Medicine Identifier:
First received: August 12, 2009
Last updated: July 12, 2011
Last verified: July 2011
The purpose of this study is to identify non-invasive biomarkers of the physiologic response to Osteopathic Manipulative Treatment (OMT).

Condition Intervention
Other: Osteopathic Manipulation
Other: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Participant)
Primary Purpose: Basic Science
Official Title: Identification of Biomarkers for Investigating Osteopathic Manipulative Treatment

Further study details as provided by West Virginia School of Osteopathic Medicine:

Primary Outcome Measures:
  • Salivary amylase levels [ Time Frame: baseline, 10 minutes post procedure ]

Enrollment: 40
Study Start Date: August 2009
Study Completion Date: December 2010
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Osteopathic Manipulation
Standardized OMT procedure
Other: Osteopathic Manipulation
Standardized rib raising protocol
Placebo Comparator: Placebo
Light touch placebo procedure
Other: Placebo
Light touch control procedure


Ages Eligible for Study:   21 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy adults between the ages of 21 and 60

Exclusion Criteria:

  • Eating or drinking anything but water or chewing gum within an hour of the appointment
  • Rib fracture
  • History of unstable cardiac arrhythmia or symptoms related to the chest cavity (difficulty breathing, chest pain)
  • Symptoms suggestive of bowel obstruction (abdominal bloating with pain, nausea and vomiting, diarrhea)
  • Pregnancy
  • History of Sjogren's Syndrome
  Contacts and Locations
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Please refer to this study by its identifier: NCT00958646

United States, West Virginia
West Virginia School of Osteopathic Medicine
Lewisburg, West Virginia, United States, 24901
Sponsors and Collaborators
West Virginia School of Osteopathic Medicine
American Osteopathic Association
Principal Investigator: Kristie G Bridges, PhD West Virginia School of Osteopathic Medicine
  More Information

Responsible Party: Kristie Grove Bridges, West Virginia School of Osteopathic Medicine Identifier: NCT00958646     History of Changes
Other Study ID Numbers: KB081209
Study First Received: August 12, 2009
Last Updated: July 12, 2011

Keywords provided by West Virginia School of Osteopathic Medicine:
Manipulation, osteopathic processed this record on May 25, 2017