We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu
IMPORTANT: Due to the lapse in government funding, the information on this web site may not be up to date, transactions submitted via the web site may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Biomarkers of the Response to Osteopathic Manipulation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00958646
Recruitment Status : Completed
First Posted : August 13, 2009
Last Update Posted : July 13, 2011
Information provided by:

Study Description
Brief Summary:
The purpose of this study is to identify non-invasive biomarkers of the physiologic response to Osteopathic Manipulative Treatment (OMT).

Condition or disease Intervention/treatment
Healthy Other: Osteopathic Manipulation Other: Placebo

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Identification of Biomarkers for Investigating Osteopathic Manipulative Treatment
Study Start Date : August 2009
Primary Completion Date : August 2010
Study Completion Date : December 2010
Arms and Interventions

Arm Intervention/treatment
Experimental: Osteopathic Manipulation
Standardized OMT procedure
Other: Osteopathic Manipulation
Standardized rib raising protocol
Placebo Comparator: Placebo
Light touch placebo procedure
Other: Placebo
Light touch control procedure

Outcome Measures

Primary Outcome Measures :
  1. Salivary amylase levels [ Time Frame: baseline, 10 minutes post procedure ]

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   21 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy adults between the ages of 21 and 60

Exclusion Criteria:

  • Eating or drinking anything but water or chewing gum within an hour of the appointment
  • Rib fracture
  • History of unstable cardiac arrhythmia or symptoms related to the chest cavity (difficulty breathing, chest pain)
  • Symptoms suggestive of bowel obstruction (abdominal bloating with pain, nausea and vomiting, diarrhea)
  • Pregnancy
  • History of Sjogren's Syndrome
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00958646

United States, West Virginia
West Virginia School of Osteopathic Medicine
Lewisburg, West Virginia, United States, 24901
Sponsors and Collaborators
West Virginia School of Osteopathic Medicine
American Osteopathic Association
Principal Investigator: Kristie G Bridges, PhD West Virginia School of Osteopathic Medicine
More Information

Responsible Party: Kristie Grove Bridges, West Virginia School of Osteopathic Medicine
ClinicalTrials.gov Identifier: NCT00958646     History of Changes
Other Study ID Numbers: KB081209
First Posted: August 13, 2009    Key Record Dates
Last Update Posted: July 13, 2011
Last Verified: July 2011

Keywords provided by West Virginia School of Osteopathic Medicine:
Manipulation, osteopathic