Autoimmune Thyroid Disease Genetic Study
Recruitment status was Active, not recruiting
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Purpose
The hypothesis of this project is that specific genes can be identified that contribute to genetic susceptibility to autoimmune thyroid disease (AITD) in different populations. The specific aim of this project is carry out one or more genomewide association studies (GWAS) to map and ultimately identify genes that confer susceptibility to AITD. AITD consists principally of Hashimoto's Thyroiditis (HT) and Graves' Disease (GD), characterized clinically generally by hypothyroidism and hyperthyroidism, respectively. Both HT and GD are autoimmune diseases characterized by infiltration of the thyroid by T and B cells that are reactive with thyroid antigens and by the production of thyroid autoantibodies (TAB). While there is some evidence that there may be genes specific to either GD or HT, other genes appear to be common to both, and some genes may furthermore be in common to susceptibility to other autoimmune diseases. Genes known to play a role in AITD include HLA, CTLA4, thyroglobulin (TG), THSR, and CD40, PTPN2, and PTPN22, several of which are also involved in susceptibility to other autoimmune diseases. All of these genes interact in a complex manner that has yet to be understood. Furthermore, it seems clear that relatively few of the genes involved in susceptibility to AITD have thus far been discovered.
| Condition |
|---|
|
Hashimoto's Disease Graves' Disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Autoimmune Thyroid Disease Genetic Study |
- Map and identify genes that confer susceptibility to Autoimmune Thyroid Disease (AITD) [ Time Frame: Approximately one year after all samples are collected ] [ Designated as safety issue: No ]SNP genotypes (allele frequencies, genotype frequencies) will be compared in cases versus controls.
| Estimated Enrollment: | 4000 |
| Study Start Date: | July 2009 |
| Estimated Study Completion Date: | February 2014 |
| Primary Completion Date: | February 2013 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Autoimmune Thyroid Disease
Patients with Hashimoto's disease or Graves' disease
|
|
Unaffected Population
Population not known to be affected by Hashimoto's Disease or Graves' Disease
|
Eligibility| Ages Eligible for Study: | 7 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Patients seen in Endocrinology Clinic
Inclusion Criteria:
- Clinical diagnosis of abnormal thyroid function (hypo or hyperthyroidism) due to autoimmune thyroid disease
Exclusion Criteria:
- Lack of documentation of abnormal thyroid function or clear evidence of autoimmune etiology
Contacts and LocationsPlease refer to this study by its ClinicalTrials.gov identifier: NCT00958113
| United States, Colorado | |
| University of Colorado Denver | |
| Aurora, Colorado, United States, 80045 | |
| Principal Investigator: | Richard Spritz, MD | University of Colorado, Denver |
More Information
No publications provided
| Responsible Party: | University of Colorado, Denver |
| ClinicalTrials.gov Identifier: | NCT00958113 History of Changes |
| Other Study ID Numbers: | 08-0931 |
| Study First Received: | August 11, 2009 |
| Last Updated: | April 9, 2013 |
| Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
|
Hashimoto Disease Thyroid Diseases Endocrine System Diseases Thyroiditis Thyroiditis, Autoimmune |
ClinicalTrials.gov processed this record on February 27, 2015