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Language Treatment for Progressive Aphasia

This study has been completed.
Canadian Institutes of Health Research (CIHR)
Information provided by (Responsible Party):
Regina Jokel, Baycrest Identifier:
First received: August 11, 2009
Last updated: January 26, 2015
Last verified: January 2015
Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking. The aim of this study is to slow the progression of language decline in progressive aphasia via language therapy. The first goal of this study is to improve naming abilities of individuals with progressive aphasia. This will be accomplished by carrying out an intensive treatment program for anomia. The second goal is to evaluate whether this intense language treatment re-activates affected areas and/or connections within the language network, using functional Magnetic Resonance Imaging (to measure neural activity in specific brain regions) and Diffusion Tensor Imaging tractography (to measure the connectivity between specific brain regions). This is the first study on progressive aphasia addressing both treatment and imaging in the same patients.

Condition Intervention
Primary Progressive Aphasia Nonfluent Progressive Aphasia Semantic Dementia Behavioral: Errorless learning

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Official Title: Slowing Language Decline in Progressive Aphasia Through Language Rehabilitation: Treatment and Neuroimaging Study

Resource links provided by NLM:

Further study details as provided by Regina Jokel, Baycrest:

Primary Outcome Measures:
  • Accuracy of picture naming [ Time Frame: 3 months ]

Secondary Outcome Measures:
  • Changes on neuroimaging [ Time Frame: 3 months ]

Enrollment: 7
Study Start Date: August 2009
Study Completion Date: December 2010
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
langauge therapy
Naming therapy
Behavioral: Errorless learning
Language testing,20 sessions of language therapy, and 2 neuroimaging sessions for participants with progressive aphasia Language testing and 1 imaging session for healthy controls
Other Name: treatment for anomia


Ages Eligible for Study:   40 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Diagnosis of progressive aphasia
  • Native English speaker or fluent in English
  • Adequate hearing and vision (not requiring more than +6 diopter correction)
  • Willing and able to participate in each phase of the study (including two fMRI sessions)

Exclusion Criteria:

  • Contraindications to fMRI (e.g., claustrophobia, pacemaker, ferromagnetic implant)
  • Current medical or psychiatric condition affecting cognition (other than progressive aphasia)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00957710

Canada, Ontario
Toronto, Ontario, Canada, M6A 2E1
Sponsors and Collaborators
Canadian Institutes of Health Research (CIHR)
Principal Investigator: Regina Jokel, PhD Baycrest
  More Information

Responsible Party: Regina Jokel, clinician scientist, Baycrest Identifier: NCT00957710     History of Changes
Other Study ID Numbers: REB 09-24
Study First Received: August 11, 2009
Last Updated: January 26, 2015

Keywords provided by Regina Jokel, Baycrest:
progressive aphasia
semantic dementia
errorless learning

Additional relevant MeSH terms:
Pick Disease of the Brain
Frontotemporal Dementia
Frontotemporal Lobar Degeneration
Aphasia, Primary Progressive
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
TDP-43 Proteinopathies
Neurodegenerative Diseases
Proteostasis Deficiencies
Metabolic Diseases processed this record on September 21, 2017