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Cancer Pain Single Nucleotide Polymorphisms (SNPs)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00956878
First Posted: August 11, 2009
Last Update Posted: December 24, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Joost LM Jongen, Erasmus Medical Center
  Purpose
Cancer pain is common in advanced cancer patients. Opioids are the mainstay of treatment in cancer pain. Responsiveness to and tolerability of opioids is, amongst others, determined by small variations in human DNA. Using blood samples from clinically well-defined cancer pain patients, the investigators are going to analyze single nucleotide polymorphisms (SNPs) in genes that are known to be involved in responsiveness to opioids and sensitivity to pain.

Condition
Cancer Pain

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Storage and Analysis of Patient Blood-samples for Cancer Pain Research

Further study details as provided by Joost LM Jongen, Erasmus Medical Center:

Primary Outcome Measures:
  • correlation between pain SNPs and equianalgesic opioid requirement [ Time Frame: timepoint at blood sample ]
    candidate SNP analysis


Biospecimen Retention:   Samples With DNA
Whole Blood

Enrollment: 243
Study Start Date: September 2008
Study Completion Date: December 2012
Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
Cancer Pain Patients

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Cancer pain patients in a large university hospital
Criteria

Inclusion Criteria:

  • Cancer pain patients

Exclusion Criteria:

  • Patients not able to provide informed consent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00956878


Locations
Netherlands
Erasmus MC, Centrumlocatie en Daniel den Hoed
Rotterdam, Zuid-Holland, Netherlands, 3000CA
Sponsors and Collaborators
Erasmus Medical Center
Investigators
Principal Investigator: Joost L Jongen, MD PhD Erasmus MC
  More Information

Additional Information:
Responsible Party: Joost LM Jongen, Dr. J.L.M. Jongen, MD, PhD, Erasmus Medical Center
ClinicalTrials.gov Identifier: NCT00956878     History of Changes
Other Study ID Numbers: MEC2008-166
First Submitted: August 10, 2009
First Posted: August 11, 2009
Last Update Posted: December 24, 2014
Last Verified: December 2014

Keywords provided by Joost LM Jongen, Erasmus Medical Center:
Cancer
Pain
SNP

Additional relevant MeSH terms:
Cancer Pain
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms