Mood and Subthalamic Nucleus (STN) Deep Brain Stimulation (MOST)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00954772
Recruitment Status : Completed
First Posted : August 7, 2009
Last Update Posted : December 2, 2011
National Parkinson Foundation
Information provided by (Responsible Party):
University of Florida

Brief Summary:
The purpose of this research study is to investigate any changes seen in mood or behavior following deep brain stimulation for movement disorders.

Condition or disease
Movement Disorders

Study Type : Observational
Actual Enrollment : 91 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Mood and STN Deep Brain Stimulation
Study Start Date : July 2005
Actual Primary Completion Date : June 2011
Actual Study Completion Date : June 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Staged Bilateral STN DBS
Simultaneous Bilateral STN DBS

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Parkinson's patients who undergo STN DBS

Inclusion Criteria:

  • Idiopathic PD diagnosed by a movement disorders neurologist
  • Approved by a movement disorders neurologist as clinically needing a DBS device
  • Absence of significant cognitive dysfunction (Mattis Dementia Rating Scale Score of greater than or equal to 116)
  • MRI without evidence of structural abnormality (stroke, tumor, malformation, etc)
  • No prior neurosurgical intervention

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00954772

United States, New York
Mt. Sinai School of Medicine
New York, New York, United States, 10029
Sponsors and Collaborators
University of Florida
National Parkinson Foundation
Principal Investigator: Michael S Okun, MD University of Florida

Responsible Party: University of Florida Identifier: NCT00954772     History of Changes
Other Study ID Numbers: 00056229
First Posted: August 7, 2009    Key Record Dates
Last Update Posted: December 2, 2011
Last Verified: August 2009

Keywords provided by University of Florida:
Staged versus Simultaneous Bilateral DBS

Additional relevant MeSH terms:
Movement Disorders
Central Nervous System Diseases
Nervous System Diseases