Inappropriate Medications Associated With Anticholinesterase and/or Memantine Treatment in the Elderly (MIDA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00954616
Recruitment Status : Completed
First Posted : August 7, 2009
Last Update Posted : March 20, 2014
Information provided by (Responsible Party):
University Hospital, Limoges

Brief Summary:
In each of the 7 French areas that should be involved, patients aged 75 years and over from three different sectors will be included: the geriatric consultation unit (60%) and two kinds of nursing homes, private (20%) and state (10%). Outpatients will be included in chronological order; patients in nursing homes will be included at random. The patients and their families will be asked about the treatments received on the day of inclusion. The inclusion period will extend over a year. The investigating practitioners will be asked to fill in a questionnaire reporting the main clinical data, adverse effects occurrence, and information on the treatment given.

Condition or disease
Alzheimer's Disease

Study Type : Observational
Actual Enrollment : 636 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Inappropriate Medications and Alzheimer Disease: Prevalence and Associated Factors in Elderly Patients Treated With Anticholinesterase and/or Memantine. MIDA Study.
Study Start Date : January 2009
Actual Primary Completion Date : July 2011
Actual Study Completion Date : January 2012

Resource links provided by the National Library of Medicine

Drug Information available for: Memantine
U.S. FDA Resources

Primary Outcome Measures :
  1. To evaluate the prevalence of PIM use in patients aged 75 years and over treated with anticholinesterase and/or memantine [ Time Frame: 2 years ]

Secondary Outcome Measures :
  1. To identify factors associated with PIM use. To study the relationship between PIM exposure and adverse effects occurrence. [ Time Frame: 2 years ]

Information from the National Library of Medicine

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Ages Eligible for Study:   75 Years and older   (Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patient of 75 and more years old affected by the Alzheimer's disease

Inclusion Criteria:

  • Patients aged 75 years and over identified as having Alzheimer disease and who have been treated for more than 3 months with anticholinesterase and/or memantine

Exclusion Criteria:

  • Patients with decompensated chronic condition or acute phase disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00954616

CHU Rouen
Rouen, Bois guillaume, France, 76 230
CHU Bordeaux
Pessac, Bordeaux, France, 33 604
CH Le Mans
Le Mans, Le Mans Cedex 1, France, 72 037
CHU Montpellier
Montpellier, Montpellier Cedex 5, France, 34 295
APHP Charles Foix
Ivry sur Seine, Paris, France, 94 205
CHU Saint Etienne
Saint Etienne, France, 42 055
Sponsors and Collaborators
University Hospital, Limoges

Responsible Party: University Hospital, Limoges Identifier: NCT00954616     History of Changes
Other Study ID Numbers: I07033
First Posted: August 7, 2009    Key Record Dates
Last Update Posted: March 20, 2014
Last Verified: August 2009

Keywords provided by University Hospital, Limoges:
Inappropriate Medications Associated
Alzheimer's disease

Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Cholinesterase Inhibitors
Antiparkinson Agents
Anti-Dyskinesia Agents
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Enzyme Inhibitors
Cholinergic Agents