Trends in Intellectual Development in Down Syndrome

The recruitment status of this study is unknown because the information has not been verified recently.

Verified March 2010 by National Taiwan University Hospital.
Recruitment status was Recruiting

Sponsor:

Information provided by:

National Taiwan University Hospital

ClinicalTrials.gov Identifier:

NCT00954382

First received: August 5, 2009

Last updated: March 16, 2010

Last verified: March 2010

History of Changes

Purpose

Previous foreign studies revealed that the IQ in Down syndrome (DS) declines with age, but not any investigation of domestic data in Taiwan was available. Individuals with DS are characterized by limited verbal development, and in this article, authors look into the diverging verbal-nonverbal abilities in the DS phenotype.

Condition
Down Syndrome


Study Type:	Observational
Study Design:	Time Perspective: Retrospective
Official Title:	Trends in Intellectual Development, and Diverging Verbal and Non-verbal Abilities in the Down Syndrome Phenotype

Resource links provided by NLM:

Genetics Home Reference related topics: CASK-related intellectual disability Down syndrome tetrasomy 18p

MedlinePlus related topics: Down Syndrome

U.S. FDA Resources

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:

IQ [ Time Frame: 2001-2010 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

mental age [ Time Frame: 2001-2010 ] [ Designated as safety issue: No ]


Estimated Enrollment:	60
Study Start Date:	May 2009
Estimated Study Completion Date:	December 2010
Estimated Primary Completion Date:	December 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts
IQ trend all subjects

Detailed Description:

The present study investigated this by analysis the test results of development /intelligence scales. To compare initial cross-sectional data with longitudinal follow-up, about 12 people with DS were included.

Eligibility


Ages Eligible for Study:	3 Months to 40 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Down syndrome

Criteria

Inclusion Criteria:

Down syndrome with psychological test results

Exclusion Criteria:

Comorbidity of severe Autism or visual/auditory impairment

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00954382

Contacts


Contact: Lih-Maan Chang, master	+886-2-23123456 ext 67211	lmchang@ntu.edu.tw

Locations


Taiwan
NTUH	Recruiting
Taipei, Taiwan, 10041
Contact: Lih-Maan Chang, master +886-2-23123456 ext 67211 lmchang@ntu.edu.tw
Principal Investigator: Wuh-Liang Hwu, Ph.D.

Sponsors and Collaborators

National Taiwan University Hospital

Investigators


Principal Investigator:	Wuh-Liang Hwu, Ph.D.	NTUH

More Information

No publications provided


Responsible Party:	Hwu Wuh-Liang, Department of Pediatrics and Medical Genetics, NTUH
ClinicalTrials.gov Identifier:	NCT00954382 History of Changes
Other Study ID Numbers:	200904037R
Study First Received:	August 5, 2009
Last Updated:	March 16, 2010
Health Authority:	Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:


Down syndrome IQ mental age neuropsychological function

Additional relevant MeSH terms:


Down Syndrome Abnormalities, Multiple Chromosome Disorders Congenital Abnormalities Genetic Diseases, Inborn	Intellectual Disability Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations

ClinicalTrials.gov processed this record on March 03, 2015

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