This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Trends in Intellectual Development in Down Syndrome

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2010 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: August 5, 2009
Last updated: March 16, 2010
Last verified: March 2010
Previous foreign studies revealed that the IQ in Down syndrome (DS) declines with age, but not any investigation of domestic data in Taiwan was available. Individuals with DS are characterized by limited verbal development, and in this article, authors look into the diverging verbal-nonverbal abilities in the DS phenotype.

Down Syndrome

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Trends in Intellectual Development, and Diverging Verbal and Non-verbal Abilities in the Down Syndrome Phenotype

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • IQ [ Time Frame: 2001-2010 ]

Secondary Outcome Measures:
  • mental age [ Time Frame: 2001-2010 ]

Estimated Enrollment: 60
Study Start Date: May 2009
Estimated Study Completion Date: December 2010
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
IQ trend
all subjects

Detailed Description:
The present study investigated this by analysis the test results of development /intelligence scales. To compare initial cross-sectional data with longitudinal follow-up, about 12 people with DS were included.

Ages Eligible for Study:   3 Months to 40 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Down syndrome

Inclusion Criteria:

  • Down syndrome with psychological test results

Exclusion Criteria:

  • Comorbidity of severe Autism or visual/auditory impairment
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00954382

Contact: Lih-Maan Chang, master +886-2-23123456 ext 67211

NTUH Recruiting
Taipei, Taiwan, 10041
Contact: Lih-Maan Chang, master    +886-2-23123456 ext 67211   
Principal Investigator: Wuh-Liang Hwu, Ph.D.         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Wuh-Liang Hwu, Ph.D. NTUH
  More Information

Responsible Party: Hwu Wuh-Liang, Department of Pediatrics and Medical Genetics, NTUH Identifier: NCT00954382     History of Changes
Other Study ID Numbers: 200904037R
Study First Received: August 5, 2009
Last Updated: March 16, 2010

Keywords provided by National Taiwan University Hospital:
Down syndrome
mental age
neuropsychological function

Additional relevant MeSH terms:
Down Syndrome
Pathologic Processes
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn processed this record on September 20, 2017