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Trends in Intellectual Development in Down Syndrome

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2010 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00954382
First Posted: August 7, 2009
Last Update Posted: March 18, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose
Previous foreign studies revealed that the IQ in Down syndrome (DS) declines with age, but not any investigation of domestic data in Taiwan was available. Individuals with DS are characterized by limited verbal development, and in this article, authors look into the diverging verbal-nonverbal abilities in the DS phenotype.

Condition
Down Syndrome

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Trends in Intellectual Development, and Diverging Verbal and Non-verbal Abilities in the Down Syndrome Phenotype

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • IQ [ Time Frame: 2001-2010 ]

Secondary Outcome Measures:
  • mental age [ Time Frame: 2001-2010 ]

Estimated Enrollment: 60
Study Start Date: May 2009
Estimated Study Completion Date: December 2010
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
IQ trend
all subjects

Detailed Description:
The present study investigated this by analysis the test results of development /intelligence scales. To compare initial cross-sectional data with longitudinal follow-up, about 12 people with DS were included.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Months to 40 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Down syndrome
Criteria

Inclusion Criteria:

  • Down syndrome with psychological test results

Exclusion Criteria:

  • Comorbidity of severe Autism or visual/auditory impairment
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00954382


Contacts
Contact: Lih-Maan Chang, master +886-2-23123456 ext 67211 lmchang@ntu.edu.tw

Locations
Taiwan
NTUH Recruiting
Taipei, Taiwan, 10041
Contact: Lih-Maan Chang, master    +886-2-23123456 ext 67211    lmchang@ntu.edu.tw   
Principal Investigator: Wuh-Liang Hwu, Ph.D.         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Wuh-Liang Hwu, Ph.D. NTUH
  More Information

Responsible Party: Hwu Wuh-Liang, Department of Pediatrics and Medical Genetics, NTUH
ClinicalTrials.gov Identifier: NCT00954382     History of Changes
Other Study ID Numbers: 200904037R
First Submitted: August 5, 2009
First Posted: August 7, 2009
Last Update Posted: March 18, 2010
Last Verified: March 2010

Keywords provided by National Taiwan University Hospital:
Down syndrome
IQ
mental age
neuropsychological function

Additional relevant MeSH terms:
Down Syndrome
Syndrome
Disease
Pathologic Processes
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn