Ibuprofen as a Possible Preventer of Post Bronchoscopy Fever
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|ClinicalTrials.gov Identifier: NCT00954200|
Recruitment Status : Unknown
Verified July 2009 by Shaare Zedek Medical Center.
Recruitment status was: Recruiting
First Posted : August 7, 2009
Last Update Posted : July 26, 2011
Scientific background: Bronchoscopy is a procedure commonly performed in the management of persistent respiratory illness. In the last decades this exam has become a routine and safe procedure even in children and there are few side-effects. However, one known side effect is transient fever and even high fever a few hours after the bronchoscopy. This side effect is not dangerous but very uncomfortable for the patients and it would be interesting to try to reduce this phenomena. This fever is due to a release of cytokines during the broncho-alveolar lavage procedure and not to sepsis. In a previous study a single dose of dexamethasone was shown to prevent the fever post bronchoscopy with no apparent detriment to the child. It is well known that steroids are immunosuppressive. Even though the post-bronchoscopy fever is not caused by an infection, it seems preferable to use other anti-inflammatory drugs to fight this very inconvenient side effect.
Ibuprofen (Nurofen*) is known as an effective medication to reduce fever in infectious illnesses and is even considered as superior to paracetamol. It has no immunosuppressive effect and is usually well tolerated by children with very few side effects when taken in the normal therapeutic dose of 10mg/Kg. The investigators postulate that a dose of Nurofen prior to bronchoscopy could significantly reduce fever post bronchoscopy.
|Condition or disease||Intervention/treatment||Phase|
|Post Bronchoscopy Fever||Drug: ibuprofen||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Ibuprofen as a Possible Preventer of Post Bronchoscopy Fever|
|Placebo Comparator: Placebo||
10mg/kg syrup - single dose
|Active Comparator: ibuprofen||
ibuprofen 10mg/kg syrup, single dose vs placeboDrug: ibuprofen
10mg/kg syrup - single dose
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00954200
|Contact: Leon j Joseph, MB ChB||00 972 2 666 firstname.lastname@example.org|
|Shaare Zedek Medical Center POB 3235||Not yet recruiting|
|Jerusalem, Israel, 91031|
|Contact: Leon J Joseph, MB ChB 00 972 2 666 6292 email@example.com|
|Principal Investigator: Leon J Joseph, MB ChB|
|Shaare Zedek Medical Center||Recruiting|
|Contact: Leon Joseph 00 972 2 666 6292|