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Ibuprofen as a Possible Preventer of Post Bronchoscopy Fever

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2009 by Shaare Zedek Medical Center.
Recruitment status was:  Recruiting
Information provided by:
Shaare Zedek Medical Center Identifier:
First received: July 26, 2009
Last updated: July 24, 2011
Last verified: July 2009

Scientific background: Bronchoscopy is a procedure commonly performed in the management of persistent respiratory illness. In the last decades this exam has become a routine and safe procedure even in children and there are few side-effects. However, one known side effect is transient fever and even high fever a few hours after the bronchoscopy. This side effect is not dangerous but very uncomfortable for the patients and it would be interesting to try to reduce this phenomena. This fever is due to a release of cytokines during the broncho-alveolar lavage procedure and not to sepsis. In a previous study a single dose of dexamethasone was shown to prevent the fever post bronchoscopy with no apparent detriment to the child. It is well known that steroids are immunosuppressive. Even though the post-bronchoscopy fever is not caused by an infection, it seems preferable to use other anti-inflammatory drugs to fight this very inconvenient side effect.

Ibuprofen (Nurofen*) is known as an effective medication to reduce fever in infectious illnesses and is even considered as superior to paracetamol. It has no immunosuppressive effect and is usually well tolerated by children with very few side effects when taken in the normal therapeutic dose of 10mg/Kg. The investigators postulate that a dose of Nurofen prior to bronchoscopy could significantly reduce fever post bronchoscopy.

Condition Intervention Phase
Post Bronchoscopy Fever Drug: ibuprofen Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Ibuprofen as a Possible Preventer of Post Bronchoscopy Fever

Resource links provided by NLM:

Further study details as provided by Shaare Zedek Medical Center:

Estimated Enrollment: 50
Arms Assigned Interventions
Placebo Comparator: Placebo Drug: ibuprofen
10mg/kg syrup - single dose
Active Comparator: ibuprofen Drug: ibuprofen
ibuprofen 10mg/kg syrup, single dose vs placebo
Drug: ibuprofen
10mg/kg syrup - single dose


Ages Eligible for Study:   up to 12 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • under twelve years of age
  • all patients undergoing bronchoscopy and bronchoalveolar lavage

Exclusion Criteria:

  • children with immune deficiency
  • allergy to NSAIDS
  • previous exacerbation of asthma due to NSAIDS
  • fever on the day of the examination
  • current antibiotic treatment
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00954200

Contact: Leon j Joseph, MB ChB 00 972 2 666 6292

Shaare Zedek Medical Center POB 3235 Not yet recruiting
Jerusalem, Israel, 91031
Contact: Leon J Joseph, MB ChB    00 972 2 666 6292   
Principal Investigator: Leon J Joseph, MB ChB         
Shaare Zedek Medical Center Recruiting
Jerusalem, Israel
Contact: Leon Joseph    00 972 2 666 6292      
Sponsors and Collaborators
Shaare Zedek Medical Center
  More Information

Publications: Identifier: NCT00954200     History of Changes
Other Study ID Numbers: 26.07.09.ctil
Study First Received: July 26, 2009
Last Updated: July 24, 2011

Additional relevant MeSH terms:
Body Temperature Changes
Signs and Symptoms
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action processed this record on June 23, 2017