Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2009 by Huashan Hospital.
Recruitment status was: Recruiting
Information provided by:
First received: August 5, 2009
Last updated: June 9, 2010
Last verified: August 2009
- To investigate the etiology, epidemiology and prognostic factors of acute kidney injury.
- To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional status.
- To study on the relationship between gene polymorphism and prognosis of acute kidney injury.
||Observational Model: Cohort
Time Perspective: Prospective
||The Study of Etiology, Epidemiology and Prognostic Factors of Acute Kidney Injury
Biospecimen Retention: Samples Without DNA
Primary Outcome Measures:
- renal function survival rate days in the hospital days in the ICU [ Time Frame: discharg from hospital, 28days,90days ] [ Designated as safety issue: Yes ]
1ml whole blood and 1ml serum will obtained within 24 hour after AKI for hematological and biochemistry analyze.
| Estimated Enrollment:
| Study Start Date:
| Estimated Study Completion Date:
| Estimated Primary Completion Date:
||December 2011 (Final data collection date for primary outcome measure)
to investigate the relationship between preexisting malnutrition and adverse outcomes in patients with AKI
- Several nutritional assessment methods such as anthropometric, clinical and biochemical evaluations have been used; however, no single indicator is considered to be a "gold standard."
- to evaluate the association of serum nutritional variables and prognosis of acute kidney injury
- Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (<7 days) and late death (>7 days, <28 days) patients.
|Ages Eligible for Study:
||16 Years to 88 Years (Child, Adult, Senior)
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Patients selected from a university-affiliated hospital in Shanghai, China.
- age >=16 years and <= 88 years
- clinically diagnosed with acute kidney injury, according RIFLE criteria.
- acute Renal Failure occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, hepatorenal syndrome, cyclosporin or tacrolimus nephrotoxicity
- Do Not Resuscitate (DNR) status
- subjects enrolled in another clinical trial that could affect the outcome of this study protocol
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00953992
|Shanghai, China, 200040 |
||Feng Ding, professor
||Feng Ding, Huashan hospital
History of Changes
|Other Study ID Numbers:
|Study First Received:
||August 5, 2009
||June 9, 2010
||China: Ethics Committee
Keywords provided by Huashan Hospital:
acute kidney disease
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on January 18, 2017
Acute Kidney Injury