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Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)

This study is currently recruiting participants.
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Verified August 2017 by Feng Ding,MD, Huashan Hospital
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Information provided by (Responsible Party):
Feng Ding,MD, Huashan Hospital Identifier:
First received: August 5, 2009
Last updated: August 30, 2017
Last verified: August 2017
  • To investigate the etiology, epidemiology and prognostic factors of acute kidney injury.
  • To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional status.
  • To study on the relationship between gene polymorphism and prognosis of acute kidney injury.

Renal Failure Nutrition Disorders

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Study of Etiology, Epidemiology and Prognostic Factors of Acute Kidney Injury

Further study details as provided by Feng Ding,MD, Huashan Hospital:

Primary Outcome Measures:
  • renal function survival rate days in the hospital days in the ICU [ Time Frame: discharg from hospital, 28days,90days ]

Biospecimen Retention:   Samples Without DNA
1ml whole blood and 1ml serum will obtained within 24 hour after AKI for hematological and biochemistry analyze.

Estimated Enrollment: 600
Study Start Date: April 2009
Estimated Study Completion Date: December 2018
Estimated Primary Completion Date: December 2017 (Final data collection date for primary outcome measure)
Detailed Description:
  1. to investigate the relationship between preexisting malnutrition and adverse outcomes in patients with AKI

    - Several nutritional assessment methods such as anthropometric, clinical and biochemical evaluations have been used; however, no single indicator is considered to be a "gold standard."

  2. to evaluate the association of serum nutritional variables and prognosis of acute kidney injury
  3. Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (<7 days) and late death (>7 days, <28 days) patients.

Ages Eligible for Study:   16 Years to 88 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients selected from a university-affiliated hospital in Shanghai, China.

Inclusion Criteria:

  • age >=16 years and <= 88 years
  • clinically diagnosed with acute kidney injury, according RIFLE or KDIGO criteria.

Exclusion Criteria:

  • acute Renal Failure occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, hepatorenal syndrome, cyclosporin or tacrolimus nephrotoxicity
  • Do Not Resuscitate (DNR) status
  • subjects enrolled in another clinical trial that could affect the outcome of this study protocol
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00953992

Contact: Feng Ding, professor 86-02152888135

Shanghai Ninth People's Hospital Recruiting
Shanghai, China, 200011
Contact: Feng Ding, professor    86-02152888135   
Sponsors and Collaborators
Huashan Hospital
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Principal Investigator: Feng Ding, professor Huashan Hospital
  More Information

Responsible Party: Feng Ding,MD, professor, Huashan Hospital Identifier: NCT00953992     History of Changes
Other Study ID Numbers: KY2009-107
Study First Received: August 5, 2009
Last Updated: August 30, 2017

Keywords provided by Feng Ding,MD, Huashan Hospital:
acute kidney disease
oxidative stress
gene polymorphism

Additional relevant MeSH terms:
Renal Insufficiency
Acute Kidney Injury
Nutrition Disorders
Kidney Diseases
Urologic Diseases processed this record on September 20, 2017