Oral Language in Children With Down Syndrome

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by University of Sao Paulo.
Recruitment status was  Active, not recruiting
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Information provided by:
University of Sao Paulo
ClinicalTrials.gov Identifier:
First received: August 3, 2009
Last updated: August 4, 2009
Last verified: August 2009
The objective of this research is to verify the language of children with Down syndrome concerning lexical, syntactic and semantic aspects using MLU. The hypothesis is that children with Down syndrome will present low performance, regarding not only the quantitative measures as MLU-m, MLU-w, GM-1 and GM-2, but also regarding the qualitative aspects of their production, when compared to children with typical development.

Condition Phase
Down Syndrome
Phase 2

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Oral Language in Children With Down Syndrome: Lexical, Syntactic and Semantic Aspects

Resource links provided by NLM:

Further study details as provided by University of Sao Paulo:

Estimated Enrollment: 60
Study Start Date: August 2007
Estimated Study Completion Date: August 2009
Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
research group
60 children aged from 3 to 10 years, both genders, observed in a symbolic play situation with their language therapists

Detailed Description:
One of the alternatives to observe and assess language development and language disorders is to analyze spontaneous language samples, which allos the identification of qualitative and quantitative aspects. The analysis involves the MLU-morphemes, MLU-words and words classes. All words produced are analyzed, including interjections, adverbs and adjectives.Word classes with grammatical characteristics present lower averages, as prepositions and conjunctions. Reference parameters are the ones of the spoken language. The objective assessment with qualitative and quantitative data may help the speech and language pathologist/therapist to determine therapeutic guidelines to each patient.

Ages Eligible for Study:   3 Years to 10 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
60 children with Down syndrome aged from 3 to 10 years

Inclusion Criteria:

  • genetic diagnosis of Down syndrome
  • good health conditions
  • normal results on audiologic evaluation
  • pediatric and ear, nose and throat periodic check ups.
  • attend speech-language therapy at the Speech Language Pathology Laboratory in Syndromes and Sensorimotor Deficits (SLPL-SSD) of the School of Medicine of the University of São Paulo.

Exclusion Criteria:

  • submission to long term hospitalizations due to heart diseases and major respiratory airway infections, that may interfere in the child's global development
  • presence of visual or auditory important deficits
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00952354

University of Sao Paulo - School of Medicine - Department of Physiotherapy, Communication Sciences and Disorders, Occupational Therapy
Sao Paulo, Brazil, 05360-160
Sponsors and Collaborators
University of Sao Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Study Chair: Suelly CO Limongi, PhD University of Sao Paulo
Principal Investigator: Rosangela V Andrade, PhD University of Sao Paulo
Principal Investigator: Fabiola C Flabiano, PhD student University of Sao Paulo
Principal Investigator: Porto Eliza, Ms student University of Sao Paulo
Principal Investigator: Angela MA Carvalho, Ms student University of Sao Paulo
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Suelly Cecilia Olivan Limongi, University of São Paulo
ClinicalTrials.gov Identifier: NCT00952354     History of Changes
Other Study ID Numbers: 473492/2007-5  CNPq-473492/2007-5 
Study First Received: August 3, 2009
Last Updated: August 4, 2009
Health Authority: Brazil: National Committee of Ethics in Research

Keywords provided by University of Sao Paulo:
Down syndrome
language development
language assessment

Additional relevant MeSH terms:
Down Syndrome
Abnormalities, Multiple
Chromosome Disorders
Congenital Abnormalities
Genetic Diseases, Inborn
Intellectual Disability
Nervous System Diseases
Neurobehavioral Manifestations
Neurologic Manifestations
Pathologic Processes

ClinicalTrials.gov processed this record on May 26, 2016