We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Myocardial Salvage Assessed by Cardiovascular Magnetic Resonance - Impact on Outcome

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00952224
First Posted: August 6, 2009
Last Update Posted: August 6, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Leipzig
  Purpose
In acute myocardial infarction cardiovascular magnetic resonance imaging can retrospectively detect the myocardium at risk and the irreversible injury. This allows for quantifying the extent of salvaged myocardium after reperfusion as a potential strong end point for clinical trials and outcome. The aim of the present study is to determine the prognostic significance and determinants of myocardial salvage assessed by CMR in reperfused ST-elevation myocardial infarction (STEMI).

Condition Intervention
ST-Elevation Myocardial Infarction Other: magnetic resonance imaging

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prognostic Significance and Determinants of Myocardial Salvage Assessed by Cardiovascular Magnetic Resonance in Acute Reperfused Myocardial Infarction

Resource links provided by NLM:


Further study details as provided by University of Leipzig:

Primary Outcome Measures:
  • Major adverse cardiac events [ Time Frame: 6 months ]

Secondary Outcome Measures:
  • Mortality [ Time Frame: 6 months ]

Enrollment: 267
Study Start Date: November 2006
Study Completion Date: March 2009
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Acute myocardial infarction patients
Patients undergoing primary percutaneous coronary intervention in ST-elevation myocardial infarction plus magnetic resonance imaging
Other: magnetic resonance imaging
magnetic resonance imaging is used for prognosis assessment

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Cohort of patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
Criteria

Inclusion Criteria:

  • ST-elevation myocardial infarction < 12 hours
  • primary percutaneous coronary intervention

Exclusion Criteria:

  • previous myocardial infarction
  • prior fibrinolysis
  • contraindications to CMR at study entry (such as implanted pacemakers, defibrillators, claustrophobia or metallic intracranial implants)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00952224


Locations
Germany
University of Leipzig - Heart Center
Leipzig, Germany, 04289
Sponsors and Collaborators
University of Leipzig
Investigators
Principal Investigator: Ingo Eitel, MD Heartcenter Leipzig GmbH
Study Director: Holger Thiele, MD Heartcenter Leipzig GmbH
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00952224     History of Changes
Other Study ID Numbers: Leipzig MR 1
First Submitted: August 3, 2009
First Posted: August 6, 2009
Last Update Posted: August 6, 2009
Last Verified: August 2009

Keywords provided by University of Leipzig:
myocardial salvage
cardiovascular magnetic resonance
magnetic resonance imaging
myocardial infarction
prognosis

Additional relevant MeSH terms:
Infarction
Myocardial Infarction
ST Elevation Myocardial Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases