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Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
Turku University Hospital
Uppsala University
Information provided by (Responsible Party):
Tampere University Hospital
ClinicalTrials.gov Identifier:
NCT00951704
First received: July 31, 2009
Last updated: April 28, 2017
Last verified: April 2017
  Purpose
The prognosis of cardiac arrest patients is generally poor. Recent studies have showed that the high quality of CPR increases the survival after cardiac arrest. Therefore the investigators planned this prospective observational study to determine the epidemiology of sudden cardiac arrest in the prehospital setting of Tampere area, the quality of the CPR, and also the associations between depth and frequency of chest compressions and invasive arterial pressure, EtCO2,cerebral oxygenation and iatrogenic injuries associated to chest compressions 1) in patients resuscitated out of hospital by emergency medical service's (EMS's) personals and 2) in-hospital by hospital resuscitation team members. In addition, the investigators will analyze the effects of the chosen method of resuscitation on critical vital signs (Etco2 and invasive pressures): closed-chest CPR is compared to open-chest CPR, or mechanical CPR with a device (AutoPulse-CPR, Cardio Pump) compared to manual CPR guided with quality CPR device. The results will give the investigators important insights into the haemodynamics of CPR which may guide future strategies for the management of cardiac arrest. The research group is also interested in CPR related injuries and mattress effect. Quality of life after CA is evaluated among survivals and the cause of death among non-survivors.

Condition
Cardiac Arrest

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluating the Quality of Prehospital and In-hospital Cardio-pulmonary Resuscitation by Reviewing Defibrillator Records - Comparing the Compressions to Concurrent Vital Signs (Invasive Blood Pressure, Cerebral Oxygen Saturation, EtCO2) and Iatrogenic Injuries Associated to Chest Compressions.

Resource links provided by NLM:


Further study details as provided by Tampere University Hospital:

Primary Outcome Measures:
  • The success rate of current guidelines (depth and frequency of chest compression, epidemiology) [ Time Frame: During the resuscitation ]
  • Quality of life after CA [ Time Frame: 6 months ]
    Quality of life after CA is usually fairly good measurement of quality of resuscitation attempt


Secondary Outcome Measures:
  • Invasive arterial pressures, cerebral oxygenation (NIRS), EtCO2 [ Time Frame: During the resuscitation ]
  • survival of cardiac arrest [ Time Frame: hospital discharge ]

Other Outcome Measures:
  • Change in hemodynamics, Change in cerebral saturation, Change in quality of CPR [ Time Frame: During resuscitation ]

Estimated Enrollment: 1000
Study Start Date: November 2008
Estimated Study Completion Date: December 2018
Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts
Cardiac arrest

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Adult population >18 years of age with cardiac arrest
Criteria

Inclusion Criteria:

  • cardiac arrest
  • > 18 years of age

Exclusion Criteria:

  • < 18 years of age
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00951704

Locations
Finland
Tampere University Hospital
Tampere, Pirkanmaa, Finland, 33521
Department of Anesthesiology and Intensive Care, Turku University Hospital
Turku, Finland, 20100
Sponsors and Collaborators
Tampere University Hospital
Turku University Hospital
Uppsala University
Investigators
Study Director: Jyrki Tenhunen, MD, PhD Critical Care Medicine Research Group
Principal Investigator: Sanna Hoppu, MD, PhD Tampere University Hospital
Principal Investigator: Marko Sainio, MD Turku University Hospital
Study Director: Klaus Olkkola, MD, PhD Department of Anesthesiology and Intensive Care, Helsinki University Hospital
Principal Investigator: Heidi Hellevuo, MD Tampere University Hospital
Principal Investigator: Piritta Setälä, MD Tampere University Hospital
Study Director: Ilkka Virkkunen, MD, PhD Tampere University Hospital
Principal Investigator: Heidi Kangasniemi, MD Tampere University Hospital
Principal Investigator: Joonas Tamminen Tampere University Hospital
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Tampere University Hospital
ClinicalTrials.gov Identifier: NCT00951704     History of Changes
Other Study ID Numbers: R08116
Study First Received: July 31, 2009
Last Updated: April 28, 2017

Keywords provided by Tampere University Hospital:
Open-chest
CPR
Tissue Perfusion
invasive arterial pressure
exhaled carbon dioxide
Quality of life
Quality of chest compressions
Epidemiology of sudden cardiac arrest(OHCA)

Additional relevant MeSH terms:
Heart Arrest
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on May 25, 2017