Potassium Intake in Patients With Chronic Kidney Disease (CKD-K)
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ClinicalTrials.gov Identifier: NCT00949585 |
Recruitment Status :
Completed
First Posted : July 30, 2009
Last Update Posted : September 19, 2012
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Condition or disease | Intervention/treatment | Phase |
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Chronic Kidney Disease Hypertension | Other: Dietary intake of potassium | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 29 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Potassium Intake in Patients With Chronic Kidney Disease |
Study Start Date : | July 2009 |
Actual Primary Completion Date : | June 2011 |
Actual Study Completion Date : | June 2011 |

Arm | Intervention/treatment |
---|---|
Dietary potassium intake: 100 mmol/day
Participants will be given one of two diets: one contains 100 mmol of potassium per day, and the other contains 40 mmol of potassium per day
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Other: Dietary intake of potassium
Comparison of two diets: one contains 100 mmol potassium per day, and the other contains 40 mmol potassium per day |
Dietary potassium intake: 40 mmol/day
Diet containing 40 mmol/day of potassium
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Other: Dietary intake of potassium
Comparison of two diets: one contains 100 mmol potassium per day, and the other contains 40 mmol potassium per day |
- 24-hour ambulatory systolic blood pressure [ Time Frame: At screening, and at the end (4th week) of each intervention period ]
- other measures of peripheral blood pressure (other types of ambulatory blood pressure measurements as well as clinic blood pressure) [ Time Frame: Ambulatory BP: same as primary outcome. Clinic BP: at screening, run-in, and weekly during intervention ]
- measures of central blood pressure (pulse wave velocity and augmentation index) [ Time Frame: at screening and at the end (4th week) of each intervention period ]
- Serum potassium [ Time Frame: At screening, run-in, and at least 3 times during each intervention period ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Stage 3 chronic kidney disease (estimated glomerular filtration rate 30-59 mL/min/1.73 m2 by the 4-variable Modification of Diet in Renal Disease (MDRD) Study Equation
- Systolic blood pressure 120-159 mm Hg and diastolic blood pressure < 100 mm Hg
- Willingness to follow strict dietary rules for 9 weeks and to come to the clinical research unit at least 3 weekdays per week for one meal during the two study periods
Exclusion Criteria:
- Baseline serum potassium of at least 5.5 mEq/L
- Baseline serum potassium of less than 3.5 mEq/L
- Insulin-requiring or uncontrolled (HbA1C > 9 g/dL) diabetes mellitus
- Use of potassium supplements
- Use of digoxin
- Chronic disease(s) that may interfere with trial participation
- Pregnancy or lactation
- > 14 alcoholic drinks/week
- Major food allergies or intolerances

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00949585
United States, Maryland | |
Johns Hopkins University Pro Health Clinical Research Facility | |
Baltimore, Maryland, United States, 21207 |
Principal Investigator: | Sharon Turban, MD, MHS | Johns Hopkins University |
Responsible Party: | Sharon Turban, Assistant Professor of Medicine, Division of Nephrology, Johns Hopkins University |
ClinicalTrials.gov Identifier: | NCT00949585 |
Other Study ID Numbers: |
AHA 0835162N |
First Posted: | July 30, 2009 Key Record Dates |
Last Update Posted: | September 19, 2012 |
Last Verified: | September 2012 |
randomized, controlled feeding study; crossover design potassium intake |
Kidney Diseases Renal Insufficiency, Chronic Urologic Diseases Renal Insufficiency |