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Effects of Buprenorphine on Ulnar Nerve Motor Block

This study has been terminated.
(Not enough could be recruted)
Information provided by (Responsible Party):
University of Zurich Identifier:
First received: July 29, 2009
Last updated: March 14, 2014
Last verified: August 2011

Recent reports showed that the opioid buprenorphine is a very potent sodium channel blocker. Buprenorphine not only exerts a strong antinociception, but also a long lasting antihyperalgesic effect. This antihyperalgesic effect is not observed for other clinically employed opioids but is common for local anaesthetics.

The principal aim of the study is to compare the speed of onset and the time of recovery of motor blockage achieved by lidocaine and buprenorphine, respectively. The investigators hypothesize that the blocking capacity of buprenorphine is equal to the one of lidocaine.

Condition Intervention Phase
Healthy Volunteers
Drug: buprenorphine
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Buprenorphine on Ulnar Nerve Motor Block

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • The principal aim of the study is to measure the speed of onset and the time of recovery of motor blockage achieved by lidocaine and buprenorphine [ Time Frame: 6 hours ]

Estimated Enrollment: 20
Study Start Date: January 2010
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: buprenorphine
    intradermal injection

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. Male
  2. Age: 18 - 65 years
  3. Weight: 50-100kg
  4. Height: 155-195cm
  5. Signed and dated informed consent
  6. Sufficient command of German language

Exclusion Criteria:

  1. Contraindications to the class of drugs under study
  2. Vulnerable subjects (intellectually or mental impaired)
  3. Known hypersensitivity to class of drugs or the investigational product
  4. Drug abuse
  5. Known peripheral neuropathies
  6. Diabetes mellitus
  7. Chronic alcohol consumption
  8. Congestive heart disease
  9. Participants of other studies during study period
  Contacts and Locations
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Please refer to this study by its identifier: NCT00949299

University Hospital Zurich, Institut of Anaesthesiology
Zurich, ZH, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Principal Investigator: Konrad Maurer, MD Oberarzt Institute of Anesthesiology
  More Information

Responsible Party: University of Zurich Identifier: NCT00949299     History of Changes
Other Study ID Numbers: Stv 2/2009
Study First Received: July 29, 2009
Last Updated: March 14, 2014

Additional relevant MeSH terms:
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Narcotic Antagonists processed this record on May 22, 2017